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liver
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blood chem panel
gene expr microarray studies, liver
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Phenotype data: liver pathology
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liver — pathology
histopathology
Paigen1
liver pathology (0-4) [score]
high-fat diet
8wks
• images
• microvacuoles
• macrovacuoles
• inflammation
43
strains
age
15-19wks
Inbred
Rusyn5
liver steatosis (0-4) [score]
high-fat diet, ethanol
• high-fat only
• high-fat and ethanol
• comparison
14
strains
age
8-14wks
Inbred
Rusyn5
liver inflammation (0-2) [score]
high-fat diet, ethanol
• high-fat only
• high-fat and ethanol
• comparison
14
strains
age
8-14wks
Inbred
Rusyn5
liver necrosis (0-2) [score]
high-fat diet, ethanol
• high-fat only
• high-fat and ethanol
• comparison
14
strains
age
8-14wks
Inbred
Rusyn5
total liver histopathology (0-8) [score]
high-fat diet, ethanol
• high-fat only
• high-fat and ethanol
• comparison
14
strains
age
8-14wks
Inbred
Threadgill1
necrosis [%]
control and
acetaminophen
• control
post-Rx mg/kg:
• 100
• 200
• 300
• comparison
37
strains
age
8-17wks
Inbred
Threadgill2
liver necrosis score
[%]
acetaminophen
300mg/kg
5
strains
age
6-8wks
Inbred
Threadgill2
percent nitrotyrosine staining (marker of hepatocyte injury)
[%]
acetaminophen
300mg/kg
5
strains
age
6-8wks
Inbred
Paigen3
liver pathology (0-4) [score]
high-fat diet
8wks
• images
• microvacuoles
• macrovacuoles
• inflammation
8
strains
age
15-19wks
obesity mutants
liver — pathology — hepatotoxicity
histopathology
Klaassen1
Cd-induced toxicity to liver
[designation]
cadmium
9
strains
age
8wks
Inbred
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