Home       About             Help       Phenotype data > DBA/2J strain > immune system Options: cell counts – peripheral blood cell counts – spleen cell counts – thymus histocompatibility morphology – thymus proteins response to infections all Focus: all Measurements: About these DBA/2J averages (♀ ♂) Exit DBA/2J mode immune system — cell counts — peripheral blood — B cells         flow cytometry   Petkova1 B cells [%]         • 6mo  ...... 78.3 ▲   64.6         • 12mo  ...... 55.2   45.1         • 18mo  ...... 59.0 ▲   56.5         • 24mo  ......         • age comparison   32 strains   ages shown   Inbred   immune system — cell counts — peripheral blood — NK cells         flow cytometry   Petkova1 NK cells [%]         • 6mo  ...... 2.91   4.46         • 12mo  ...... 1.51   1.53         • 18mo  ...... 2.12   2.48         • 24mo  ......         • age comparison   32 strains   ages shown   Inbred   immune system — cell counts — peripheral blood — T cells         flow cytometry   Petkova1 CD4 T cells [%]         • 6mo  ...... 2.84 ▼   18.2         • 12mo  ...... 16.9   20.3         • 18mo  ...... 12.2   12.9         • 24mo  ......         • age comparison   32 strains   ages shown   Inbred Petkova1 CD4 T cells - naive cells [%]         • 6mo  ...... 33.4   25.8         • 12mo  ...... 46.0   67.6         • 18mo  ...... 37.7   55.5         • 24mo  ......         • age comparison   32 strains   ages shown   Inbred Petkova1 CD4 T cells - central memory cells [%]         • 6mo  ...... 3.17   2.53         • 12mo  ...... 6.85   6.43         • 18mo  ...... 6.78   8.72 ▲         • 24mo  ......         • age comparison   32 strains   ages shown   Inbred Petkova1 CD4 T cells - effector memory cells [%]         • 6mo  ...... 13.0   15.0         • 12mo  ...... 25.3   16.3         • 18mo  ...... 32.0   20.7         • 24mo  ......         • age comparison   32 strains   ages shown   Inbred Petkova1 CD4 T cells - effector cells [%]         • 6mo  ...... 50.4   56.6         • 12mo  ...... 21.8   9.62         • 18mo  ...... 23.5   15.2         • 24mo  ......         • age comparison   32 strains   ages shown   Inbred Petkova1 CD8 T cells [%]         • 6mo  ...... 7.96   7.25         • 12mo  ...... 11.1   7.20 ▼         • 18mo  ...... 11.0   7.44 ▼         • 24mo  ......         • age comparison   32 strains   ages shown   Inbred Petkova1 CD8 T cells - naive cells [%]         • 6mo  ...... 42.4   32.5         • 12mo  ...... 45.3   52.9         • 18mo  ...... 28.4   48.3         • 24mo  ......         • age comparison   32 strains   ages shown   Inbred Petkova1 CD8 T cells - central memory cells [%]         • 6mo  ...... 20.6 ▲   13.7         • 12mo  ...... 29.1   32.3         • 18mo  ...... 32.2   41.2 ▲         • 24mo  ......         • age comparison   32 strains   ages shown   Inbred Petkova1 CD8 T cells - effector memory cells [%]         • 6mo  ...... 10.5   16.4         • 12mo  ...... 18.9   11.1         • 18mo  ...... 29.8 ▲   7.03         • 24mo  ......         • age comparison   32 strains   ages shown   Inbred Petkova1 CD8 T cells - effector cells [%]         • 6mo  ...... 26.5   37.4         • 12mo  ...... 6.71   3.64         • 18mo  ...... 9.63   3.47         • 24mo  ......         • age comparison   32 strains   ages shown   Inbred   immune system — cell counts — spleen         flow cytometry   Benoist1 CD4 T cells [%]         • CD25hi  ...... 11.4 (N=3) ▲         • Foxp3+  ......         • comparison   31 strains   age 5-6wks   Inbred Jaxpheno6 CD4 T cells [%]         • 8wks  ...... 9.61   10.1         • 16wks  ......         • age comparison   11 strains   ages shown   Inbred Jaxpheno6 CD8 T cells [%]         • 8wks  ...... 4.39 ▼   4.08 ▼         • 16wks  ......         • age comparison   11 strains   ages shown   Inbred Jaxpheno6 NK T cells [%]         • 8wks  ...... 0.651   0.510         • 16wks  ......         • age comparison   11 strains   ages shown   Inbred Jaxpheno6 NK cells [%]         • 8wks  ...... 2.38   1.53         • 16wks  ......         • age comparison   11 strains   ages shown   Inbred Jaxpheno6 B cells [%]         • 8wks  ...... 65.3 ▲   62.9         • 16wks  ......         • age comparison   11 strains   ages shown   Inbred Jaxpheno6 granulocytes [%]         • 8wks  ...... 1.89   1.63         • 16wks  ......         • age comparison   11 strains   ages shown   Inbred Jaxpheno6 monocytes [%]         • 8wks  ...... 3.96   2.94         • 16wks  ......         • age comparison   11 strains   ages shown   Inbred   immune system — cell counts — thymus         flow cytometry   Benoist1 CD4 T cells [%]         • CD25hi  ...... 4.95 (N=3)         • Foxp3+  ......         • comparison   33 strains   age 5-6wks   Inbred   immune system — histocompatibility — MHC haplotype   Jax2 major histocompatibility complex (MHC) H2 haplotype   [designation] ...... d d 57 strains     Inbred   immune system — morphology — thymus         scales   Deschepper1 thymus weight [mg]         • weight  ...... 33.4   52.8         • normalized  ...... 1.78   2.23         13 strains   age 10wks   Inbred   immune system — proteins — misc         PCR   Gros1 complement component 5 (C5) allele (0=deficient, 1=sufficient)   [designation] ...... 0 ▼   36 strains   age 8-12wks   Inbred   immune system — response to bacterial infection — anthrax         in vitro assay   Dietrich1 macrophage susceptibility to Bacillus anthracis lethal toxin (0=susceptible; 1=resistant)   [designation] ...... 1 ▲     Bacillus anthracis lethal toxin   50 strains   age 6-8wks*   Inbred   immune system — response to fungal infection — candidiasis         colony-forming units   Gros1 kidney fungal load 48h post-infection, colony-forming units (log10 CFU per kidney)   [n] ...... 5.30 ▲     Candida albicans   23 strains   age 8-12wks   Inbred Gros1 susceptibility to C. albicans based on fungal load (0=susceptible; 1=resistant)   [designation] ...... 0 ▼     Candida albicans   23 strains   age 8-12wks   Inbred   immune system — response to parasitic infection — malaria         flow cytometry   Bopp1 parasite distribution in selected organs [%]   Plasmodium berghei         • brain  ...... 6.26 (N=3) ▲   3.82 (N=1)         • spleen  ...... 10.3 (N=3)   4.46 (N=1) ▼         • lungs  ...... 62.5 (N=3) ▲   84.0 (N=1) ▲▲         • liver  ...... 20.9 (N=3)   7.76 (N=1) ▼           • comparison   26 strains   age 8-12wks   Inbred   immune system — response to parasitic infection — malaria         observation   Bopp1 response to infection   Plasmodium berghei         • survival  ...... 13.8 (N=4) ▲   12.8 (N=4) ▲         • body temperature  ...... 26.8 (N=3) ▼   25.9 (N=4) ▼         • parasite load  ...... 67.0 (N=4) ▲   52.0 (N=4)         31 strains   age 8-12wks   Inbred   immune system — response to viral infection         observation   Boon1 survival [d]   influenza A (H5N1) virus       dosage group:             • low  ...... 19.0 ▼               • medium  ...... 7.96 ▼               • high  ...... 7.47                 • comparison   18 strains   age 6-9wks   Inbred Boon1 susceptibility to viral infection [designation]   influenza A (H5N1) virus       dosage group:             • low  ...... 0.433 ▼               • medium  ...... 0 ▼               • high  ...... 0.0667                 • comparison   18 strains   age 6-9wks   Inbred Schughart1 susceptibility to viral infection (0=susceptible; 1=resistant)   [designation] ...... 0 ▼     influenza A (H1N1) virus   9 strains   age 10-12wks   Inbred

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