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Phenotype data
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cardiovascular
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aorta and ventricle dimensions
atherosclerosis
blood pressure
ECG parameters
echocardiography
heart rate
heart weight
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Phenotype data: cardiovascular all
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cardiovascular — aorta and ventricle dimensions
echocardiography
Eumorphia6
cardiac ventricular dimension [mm]
• left ventricular wall at diastole
• left ventricular wall at systole
• ventricular septum
• right ventricular wall
4
strains
age
12wks
Inbred
Eumorphia6
cardiac aorta morphologic characteristics [mm]
• diameter
• volume change
4
strains
age
12wks
Inbred
Jaxpheno8
intra-ventricular septum thickness [mm]
• diastolic
• systolic
• comparison
6
strains
age
12wks
Inbred
Jaxpheno8
left ventricle anterior wall thickness [mm]
• diastolic
• systolic
• comparison
6
strains
age
12wks
Inbred
Jaxpheno8
left ventricle posterior wall thickness [mm]
• diastolic
• systolic
• comparison
6
strains
age
12wks
Inbred
Jaxpheno8
left ventricle internal dimension [mm]
• diastolic
• systolic
• comparison
6
strains
age
12wks
Inbred
Jaxpheno8
left ventricle volume [µL]
• diastolic
• systolic
• comparison
6
strains
age
12wks
Inbred
cardiovascular — atherosclerosis
histopathology
Paigen1
fatty streak aortic lesion size
[µm
2
]
high-fat diet
8wks
43
strains
age
15-19wks
Inbred
Paigen2
fatty streak aortic lesion size
[µm
2
]
high-fat diet
17wks
43
strains
age
25-27wks
Inbred
Paigen3
fatty streak aortic lesion size
[µm
2
]
high-fat diet
8wks
8
strains
age
15-19wks
obesity mutants
cardiovascular — blood pressure
tail cuff
Composite
systolic blood pressure
BP
Inbred
Deschepper1
systolic blood pressure
[mmHg]
13
strains
age
10wks
Inbred
Gavras1
systolic blood pressure [mmHg]
control and
salt (NaCl)
1%soln 2wks
• control
• NaCl
• comparison
11
strains
age
9-12wks
Inbred
Jaxwest1
systolic blood pressure
[mmHg]
7
strains
age
9-14wks
Inbred
Maurer1
systolic blood pressure [mmHg]
control and
atenolol, isoproterenol
2wks
• control
• atenolol 10mg
• isoprot 1mg
• isoprot 10mg
• comparison
23
strains
age
7-13wks
Inbred
Sugiyama1
blood pressure [mmHg]
• systolic
• diastolic
25
strains
age
10wks
Inbred
Svenson1
systolic blood pressure
[mmHg]
14
strains
age
9wks
Inbred
Lake1
systolic blood pressure
[mmHg]
23
strains
age
10wks
B6.A consomic
CGDpheno3
systolic blood pressure
[mmHg]
24
strains
age
10wks
CC diallel
cardiovascular — ECG parameters — conscious
ECG
Hampton1
intervals [ms]
• RR
• PQ
• PR
• QRS
17
strains
age
9-12wks
Inbred
Jaxwest1
intervals [ms]
• RR
• PQ
• PR
• QRS
• QT
• QTc
• ST
7
strains
age
8-10wks
Inbred
Xing1
interval RR [ms]
• 6mo
• 12mo
• 20mo
• age comparison
29
strains
ages shown
Inbred
Xing1
interval PR [ms]
• 6mo
• 12mo
• 20mo
• age comparison
29
strains
ages shown
Inbred
Xing1
interval QRS [ms]
• 6mo
• 12mo
• 20mo
• age comparison
29
strains
ages shown
Inbred
Xing1
interval QT [ms]
• 6mo
• 12mo
• 20mo
• age comparison
29
strains
ages shown
Inbred
Xing1
interval ST [ms]
• 6mo
• 12mo
• 20mo
• age comparison
29
strains
ages shown
Inbred
Lake1
intervals [ms]
• RR
• PQ
• PR
• QRS
• QT
• QTc
• QT dispersion
• QTc dispersion
23
strains
age
11wks
B6.A consomic
CGDpheno3
wave amplitudes [mV]
• R
• R+S
42
strains
age
12wks
CC diallel
CGDpheno3
intervals [ms]
• RR
• PQ
• PR
• QRS
• QT
• QTc
• QT dispersion
• QTc dispersion
• ST
42
strains
age
12wks
CC diallel
cardiovascular — ECG parameters — unconscious
ECG
Maurer1
amplitude of P-wave [mV]
control and
atenolol, isoproterenol
2wks
• control
• atenolol 10mg
• isoprot 1mg
• isoprot 10mg
• comparison
23
strains
age
7-13wks
Inbred
Maurer1
amplitude of Q-wave [mV]
control and
atenolol, isoproterenol
2wks
• control
• atenolol 10mg
• isoprot 1mg
• isoprot 10mg
• comparison
23
strains
age
7-13wks
Inbred
Maurer1
amplitude of R-wave [mV]
control and
atenolol, isoproterenol
2wks
• control
• atenolol 10mg
• isoprot 1mg
• isoprot 10mg
• comparison
23
strains
age
7-13wks
Inbred
Maurer1
amplitude of S-wave [mV]
control and
atenolol, isoproterenol
2wks
• control
• atenolol 10mg
• isoprot 1mg
• isoprot 10mg
• comparison
23
strains
age
7-13wks
Inbred
Maurer1
duration P-wave [ms]
control and
atenolol, isoproterenol
2wks
• control
• atenolol 10mg
• isoprot 1mg
• isoprot 10mg
• comparison
23
strains
age
7-13wks
Inbred
Maurer1
interval PR [ms]
control and
atenolol, isoproterenol
2wks
• control
• atenolol 10mg
• isoprot 1mg
• isoprot 10mg
• comparison
23
strains
age
7-13wks
Inbred
Maurer1
interval RR [ms]
control and
atenolol, isoproterenol
2wks
• control
• atenolol 10mg
• isoprot 1mg
• isoprot 10mg
• comparison
23
strains
age
7-13wks
Inbred
Maurer1
interval QRS [ms]
control and
atenolol, isoproterenol
2wks
• control
• atenolol 10mg
• isoprot 1mg
• isoprot 10mg
• comparison
23
strains
age
7-13wks
Inbred
Maurer1
interval QT [ms]
control and
atenolol, isoproterenol
2wks
• control
• atenolol 10mg
• isoprot 1mg
• isoprot 10mg
• comparison
23
strains
age
7-13wks
Inbred
Maurer1
interval ST [ms]
control and
atenolol, isoproterenol
2wks
• control
• atenolol 10mg
• isoprot 1mg
• isoprot 10mg
• comparison
23
strains
age
7-13wks
Inbred
Maurer1
area of P-wave [ms*mV]
control and
atenolol, isoproterenol
2wks
• control
• atenolol 10mg
• isoprot 1mg
• isoprot 10mg
• comparison
23
strains
age
7-13wks
Inbred
Maurer1
area of QRS [ms*mV]
control and
atenolol, isoproterenol
2wks
• control
• atenolol 10mg
• isoprot 1mg
• isoprot 10mg
• comparison
23
strains
age
7-13wks
Inbred
Maurer1
area of QTc [ms*mV]
control and
atenolol, isoproterenol
2wks
• control
• atenolol 10mg
• isoprot 1mg
• isoprot 10mg
• comparison
23
strains
age
7-13wks
Inbred
cardiovascular — echocardiography
echocardiography
Eumorphia6
cardiac-ventricular performance [%]
• fractional shortening
• ejection fraction
• cardiac output
4
strains
age
12wks
Inbred
Eumorphia6
mitral valve outflow characteristics [ms]
• A-wave duration
• E-wave deceleration
• mitral valve E-wave area
• mitral valve A-wave area
• E/A ratio
• isovolumetric contraction
• isovolumetric relaxation
4
strains
age
12wks
Inbred
Jaxpheno8
aortic blood pressure gradients [mmHg]
• mean peak pressure gradient
• maximum pressure gradient
• comparison
6
strains
age
12wks
Inbred
Jaxpheno8
aortic blood flow velocities
• velocity
• mean velocity
• maximum velocity
• velocity time integral
• comparison
6
strains
age
12wks
Inbred
Jaxpheno8
heart rate, M-Mode parasternal short axis
[n/min]
6
strains
age
12wks
Inbred
Jaxpheno8
left ventricle performance
• cardiac output
• ejection fraction
• fractional shortening
• stroke volume
6
strains
age
12wks
Inbred
Jaxpheno8
mitral valve blood flow characteristics [mm/s]
• peak A-wave
• peak E-wave
• comparison
6
strains
age
12wks
Inbred
Jaxpheno8
tricuspid valve blood flow characteristics [mm/s]
• peak A-wave
• peak E-wave
• comparison
6
strains
age
12wks
Inbred
Jaxpheno8
pulmonary artery blood flow velocities
• velocity
• mean velocity
• maximum velocity
• velocity time integral
• comparison
6
strains
age
12wks
Inbred
Jaxpheno8
pulmonary artery blood pressure gradients [mmHg]
• mean pressure gradient
• maximum pressure gradient
• comparison
6
strains
age
12wks
Inbred
cardiovascular — heart rate — conscious
ECG
Hampton1
heart rate [n/min]
• heart rate
• variability
17
strains
age
9-12wks
Inbred
Jaxwest1
heart rate [n/min]
• heart rate
• variability
• CV
7
strains
age
8-10wks
Inbred
Xing1
heart rate [n/min]
• 6mo
• 12mo
• 20mo
• age comparison
29
strains
ages shown
Inbred
Lake1
heart rate [n/min]
• heart rate
• variability
• CV
23
strains
age
11wks
B6.A consomic
CGDpheno3
heart rate [n/min]
• heart rate
• CV
42
strains
age
12wks
CC diallel
cardiovascular — heart rate — conscious
tail cuff
Eumorphia6
pulse rate
[n/min]
4
strains
age
12wks
Inbred
Gavras1
pulse rate [n/min]
control and
salt (NaCl)
1%soln 2wks
• control
• NaCl
• comparison
11
strains
age
9-12wks
Inbred
Jaxwest1
pulse rate
[n/min]
7
strains
age
9-14wks
Inbred
Maurer1
pulse rate [n/min]
control and
atenolol, isoproterenol
2wks
• control
• atenolol 10mg
• isoprot 1mg
• isoprot 10mg
• comparison
23
strains
age
7-13wks
Inbred
Sugiyama1
pulse rate
[n/min]
25
strains
age
10wks
Inbred
Svenson1
pulse rate [n/min]
• pulse rate
• variability
14
strains
age
9wks
Inbred
Lake1
pulse rate [n/min]
• pulse rate
• variability
23
strains
age
10wks
B6.A consomic
CGDpheno3
pulse rate
[n/min]
24
strains
age
10wks
CC diallel
cardiovascular — heart rate — unconscious
ECG
Maurer1
heart rate [n/min]
control and
atenolol, isoproterenol
2wks
• control
• atenolol 10mg
• isoprot 1mg
• isoprot 10mg
• comparison
23
strains
age
7-13wks
Inbred
cardiovascular — heart weight
scales
Deschepper1
ventricle weight [mg]
weight:
• both
• left
• right
normalized:
• both
• left
• right
13
strains
age
10wks
Inbred
Deschepper1
atria weight [mg]
weight:
• both
• left
• right
normalized:
• both
• left
• right
13
strains
age
10wks
Inbred
Eumorphia6
left ventricle weight [mg]
• weight
• normalized
4
strains
age
12wks
Inbred
Jaxpheno2
heart weight [g]
• age 8wks
• age 16wks
• age comparison
11
strains
ages shown
Inbred
Jaxpheno2
heart weight as percent of body weight [%]
• age 8wks
• age 16wks
• age comparison
11
strains
ages shown
Inbred
Maurer1
heart weight [mg]
control and
atenolol, isoproterenol
2wks
weight:
• control
• atenolol 10mg
• isoprot 1mg
• isoprot 10mg
• comparison
normalized:
• control
• atenolol 10mg
• isoprot 1mg
• isoprot 10mg
• comparison
23
strains
age
7-13wks
Inbred
Maurer1
atria weight [mg]
control and
atenolol, isoproterenol
2wks
weight:
• control
• atenolol 10mg
• isoprot 1mg
• isoprot 10mg
• comparison
normalized:
• control
• atenolol 10mg
• isoprot 1mg
• isoprot 10mg
• comparison
23
strains
age
7-13wks
Inbred
Maurer1
ventricle (both) weight [mg]
control and
atenolol, isoproterenol
2wks
weight:
• control
• atenolol 10mg
• isoprot 1mg
• isoprot 10mg
• comparison
normalized:
• control
• atenolol 10mg
• isoprot 1mg
• isoprot 10mg
• comparison
23
strains
age
7-13wks
Inbred
Maurer1
atria weight to ventricle weight ratio [ratio]
control and
atenolol, isoproterenol
2wks
• control
• atenolol 10mg
• isoprot 1mg
• isoprot 10mg
• comparison
23
strains
age
7-13wks
Inbred
Reed1
heart weight
• weight [g]
• as percent of body weight [%]
28
strains
age
29-67wks
Inbred
Chesler2
heart weight
[g]
62
strains
age
various
CC diallel
Chesler3
heart weight
[g]
age
various
CC pre
Cheverud1
heart weight as percent of body weight [%]
control and
high-fat diet
17wks
• control diet
• high-fat diet
• comparison
19
strains
age
20-30wks
LGXSM
243 measurements listed.
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