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blood – lipids
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cholesterol – HDL
cholesterol – LDL or non-HDL
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clinical chemistry
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cholesterol – HDL
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Phenotype data: blood--lipids cholesterol – HDL
Measurements:
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blood — lipids — cholesterol — HDL
lipid profile
Composite
HDL cholesterol
HDL
Inbred
Albers1
HDL cholesterol [mmol/L]
baseline and
high-fat diet
6wks
• baseline
• after 6wks on diet
• Δchange
• comparison
15
strains
age
6-8wks
at baseline
Inbred
Albers1
percentage of large HDL particles (10-13 nm) [%]
baseline and
high-fat diet
6wks
• baseline
• after 6wks on diet
• Δchange
• comparison
15
strains
age
6-8wks
at baseline
Inbred
Albers1
HDL peak size [nm]
baseline and
high-fat diet
6wks
• baseline
• after 6wks on diet
• Δchange
• comparison
15
strains
age
6-8wks
at baseline
Inbred
CGDpheno1
HDL cholesterol (plasma HDL)
[mg/dL]
72
strains
age
12wks
Inbred
Eumorphia1
HDL cholesterol (plasma HDL)
[mg/dL]
4
strains
age
12wks
Inbred
Jaxpheno3
HDL cholesterol [mg/dL]
• age 8wks
• age 16wks
• age comparison
11
strains
ages shown
Inbred
Paigen1
HDL cholesterol (plasma)
high-fat diet
8wks
• amount
• % of total plasma cholesterol
43
strains
age
15-19wks
Inbred
Paigen2
HDL cholesterol [mg/dL]
baseline and
high-fat diet
17wks
• baseline
• after 17wks on diet
• Δchange
• comparison
43
strains
age
7-9wks
at baseline
Inbred
Paigen4
HDL cholesterol
[mg/dL]
43
strains
age
10wks
Inbred
RIKEN-EAD1
HDL cholesterol (plasma HDL)
[mg/dL]
35
strains
age
8wks
Inbred
Shockley1
HDL cholesterol (HDL) [mg/dL]
control and
high-fat diet
4wks
• control diet
• high-fat diet
• difference
• comparison
10
strains
age
10-13wks
Inbred
Yuan3
HDL cholesterol (plasma HDL) [mg/dL]
• 6mo
• 12mo
• 18mo
• age comparison
32
strains
ages shown
Inbred
Lake1
HDL cholesterol (plasma HDL)
[mg/dL]
23
strains
age
8wks
B6.A consomic
Svenson3
HDL cholesterol (plasma HDL)
[mg/dL]
28
strains
age
8wks
B6.PWD consomic
CGDpheno3
HDL cholesterol (plasma HDL)
[mg/dL]
62
strains
age
8wks
CC diallel
HMDPpheno2
HDL cholesterol (plasma HDL) [mg/dL]
• all HMDP
• inbreds
• AXB BXA
• BXD
• BXH
• comparison
99
strains
age
16wks
HMDP
Paigen3
HDL cholesterol (plasma)
high-fat diet
8wks
• amount
• % of total plasma cholesterol
8
strains
age
15-19wks
obesity mutants
RIKEN-EAD2
HDL cholesterol (plasma HDL)
[mg/dL]
26
strains
age
8wks
wild-derived RBRC
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