blood — clinical chemistry — bilirubin         metabolic panel   CGDpheno1 total bilirubin (plasma TBIL)   [µmol/L] 72 strains   age 12wks   Inbred Eumorphia1 total bilirubin (plasma TBIL)   [µmol/L] 4 strains   age 12wks   Inbred RIKEN-EAD1 total bilirubin (plasma TBIL)   [mg/dL] 35 strains   age 8wks   Inbred Yuan3 bilirubin (serum TBIL) [µmol/L]         • 6mo  • 12mo  • 18mo    • age comparison   31 strains   ages shown   Inbred Lake1 total bilirubin (plasma TBIL)   [mg/dL] 23 strains   age 8wks   B6.A consomic Donahue9 total bilirubin (plasma TBIL)   [mg/dL] 25 strains   age 11wks   B6.PWD consomic Svenson3 total bilirubin (plasma TBIL)   [mg/dL] 21 strains   age 8wks   B6.PWD consomic RIKEN-EAD2 total bilirubin (plasma TBIL)   [mg/dL] 26 strains   age 8wks   wild-derived RBRC   blood — clinical chemistry — electrolytes — anion gap         metabolic panel   Chesler2 anion gap concentration (mEq/L)   [mmol/L] 62 strains   age various   CC diallel Chesler3 anion gap concentration (mEq/L)   [mmol/L] age various   CC pre   blood — clinical chemistry — electrolytes — calcium         metabolic panel   Eumorphia1 calcium (plasma Ca)   [mg/dL] 6 strains   age 12wks   Inbred Jaxpheno3 calcium [mg/dL]         • age 8wks  • age 16wks    • age comparison   11 strains   ages shown   Inbred RIKEN-EAD1 calcium (plasma Ca)   [mg/dL] 35 strains   age 8wks   Inbred Shockley1 calcium (Ca) [mg/dL]     control and  high-fat diet 4wks       • control diet   • high-fat diet   • difference    • comparison   10 strains   age 10-13wks   Inbred Tordoff3 blood ionized calcium [mg/dL]         • Ca   • Ca adj to pH 7.4    • comparison   40 strains   age 13-15wks   Inbred Tordoff3 plasma total calcium   [mg/dL] 40 strains   age 13-15wks   Inbred Yuan3 calcium (serum Ca) [mg/dL]         • 6mo  • 12mo  • 18mo    • age comparison   31 strains   ages shown   Inbred Donahue9 calcium (serum Ca)   [mg/dL] 25 strains   age 11wks   B6.PWD consomic Chesler2 calcium (blood ionized Ca)   [mmol/L] 62 strains   age various   CC diallel Chesler3 calcium (blood ionized Ca)   [mmol/L] age various   CC pre RIKEN-EAD2 calcium (plasma Ca)   [mg/dL] 26 strains   age 8wks   wild-derived RBRC   blood — clinical chemistry — electrolytes — chloride         metabolic panel   CGDpheno1 chloride (plasma Cl)   [mmol/L] 72 strains   age 10wks   Inbred Eumorphia1 chloride (plasma Cl)   [mmol/L] 6 strains   age 12wks   Inbred Yuan3 chloride (serum Cl) [mmol/L]         • 6mo  • 12mo  • 18mo    • age comparison   31 strains   ages shown   Inbred Donahue9 chloride (serum Cl)   [mmol/L] 25 strains   age 11wks   B6.PWD consomic Chesler2 chloride (blood Cl)   [mmol/L] 62 strains   age various   CC diallel Chesler3 chloride (blood Cl)   [mmol/L] age various   CC pre   blood — clinical chemistry — electrolytes — iron         metabolic panel   Eumorphia1 iron (plasma Fe)   [µmol/L] 4 strains   age 12wks   Inbred RIKEN-EAD1 iron (plasma Fe)   [µg/dL] 35 strains   age 8wks   Inbred Yuan3 iron (serum Fe) [mmol/L]         • 6mo  • 12mo  • 18mo    • age comparison   31 strains   ages shown   Inbred RIKEN-EAD2 iron (plasma Fe)   [µg/dL] 26 strains   age 8wks   wild-derived RBRC   blood — clinical chemistry — electrolytes — magnesium         metabolic panel   Yuan3 magnesium (serum Mg) [mmol/L]         • 6mo  • 12mo  • 18mo    • age comparison   31 strains   ages shown   Inbred Donahue9 magnesium (serum Mg)   [mg/dL] 25 strains   age 11wks   B6.PWD consomic   blood — clinical chemistry — electrolytes — phosphorus         metabolic panel   Eumorphia1 phosphorus (plasma P)   [mg/dL] 6 strains   age 12wks   Inbred Jaxpheno3 phosphorus [mg/dL]         • age 8wks  • age 16wks    • age comparison   11 strains   ages shown   Inbred RIKEN-EAD1 inorganic phosphorus (plasma PO4)   [mg/dL] 35 strains   age 8wks   Inbred Yuan3 phosphorus (serum P) [mg/dL]         • 6mo  • 12mo  • 18mo    • age comparison   31 strains   ages shown   Inbred Donahue9 phosphorus (serum P)   [mg/dL] 25 strains   age 11wks   B6.PWD consomic RIKEN-EAD2 inorganic phosphorus (plasma PO4)   [mg/dL] 26 strains   age 8wks   wild-derived RBRC   blood — clinical chemistry — electrolytes — potassium         metabolic panel   CGDpheno1 potassium (plasma K)   [mmol/L] 72 strains   age 10wks   Inbred Eumorphia1 potassium (plasma K)   [mmol/L] 6 strains   age 12wks   Inbred Yuan3 potassium (serum K) [mmol/L]         • 6mo  • 12mo  • 18mo    • age comparison   31 strains   ages shown   Inbred Donahue9 potassium (serum K)   [mmol/L] 25 strains   age 11wks   B6.PWD consomic Chesler2 potassium (blood K)   [mmol/L] 62 strains   age various   CC diallel Chesler3 potassium (blood K)   [mmol/L] age various   CC pre   blood — clinical chemistry — electrolytes — sodium         metabolic panel   CGDpheno1 sodium (plasma Na)   [mmol/L] 72 strains   age 10wks   Inbred Eumorphia1 sodium (plasma Na)   [mmol/L] 6 strains   age 12wks   Inbred Yuan3 sodium (serum Na) [mmol/L]         • 6mo  • 12mo  • 18mo    • age comparison   31 strains   ages shown   Inbred Donahue9 sodium (serum Na)   [mmol/L] 25 strains   age 11wks   B6.PWD consomic Chesler2 sodium (blood Na)   [mmol/L] 62 strains   age various   CC diallel Chesler3 sodium (blood Na)   [mmol/L] age various   CC pre   blood — clinical chemistry — enzymes — ALP         metabolic panel   Eumorphia1 alkaline phosphatase (plasma ALP)   [IU/L] 4 strains   age 12wks   Inbred RIKEN-EAD1 alkaline phosphatase (plasma ALP)   [IU/L] 35 strains   age 8wks   Inbred Yuan3 alkaline phosphatase (serum ALP) [IU/L]         • 6mo  • 12mo  • 18mo    • age comparison   31 strains   ages shown   Inbred Donahue9 alkaline phosphatase (serum ALP)   [IU/L] 25 strains   age 11wks   B6.PWD consomic RIKEN-EAD2 alkaline phosphatase (plasma ALP)   [IU/L] 26 strains   age 8wks   wild-derived RBRC   blood — clinical chemistry — enzymes — ALT         metabolic panel   Eumorphia1 alanine aminotransferase (plasma ALT)   [IU/L] 4 strains   age 12wks   Inbred Harrill2 alanine aminotransferase (serum ALT) [IU/L]     control and  DB289       • control  • DB289  • difference  34 strains   age 6-8wks   Inbred Jaxpheno3 alanine aminotransferase (plasma ALT) [IU/L]         • age 8wks  • age 16wks    • age comparison   11 strains   ages shown   Inbred Paigen1 alanine aminotransferase (plasma ALT)   [IU/L]   high-fat diet 8wks 43 strains   age 15-19wks   Inbred RIKEN-EAD1 alanine aminotransferase (plasma ALT)   [IU/L] 35 strains   age 8wks   Inbred Rusyn2 alanine aminotransferase (serum ALT), naive   [IU/L] 17 strains   age 7wks   Inbred Rusyn2 alanine aminotransferase (serum ALT) [IU/L]     control and  trichloroethylene         control group:    • 2h    • 8h    • 24h    • time comparison           treated group:    • 2h    • 8h    • 24h    • time comparison   17 strains   age 7wks   Inbred Rusyn2 ALT, control vs. treated   trichloroethylene       2h  8h  24h  17 strains   age 7wks   Inbred Rusyn5 serum alanine aminotransferase (ALT) [IU/L]   high-fat diet , ethanol       • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Threadgill1 alanine aminotransferase (serum ALT) [IU/L]     control and  acetaminophen       100 mg/kg:   • control  • 4h  • 12h  • 24h    • time comparison   37 strains   age 8-17wks   Inbred Threadgill2 alanine aminotransferase (serum ALT) [IU/L]   acetaminophen 50mg/kg       • 50 mg/kg  • 300 mg/kg    • comparison   5 strains   age 6-8wks   Inbred Yuan3 alanine animotransferase (plasma ALT) [IU/L]         • 6mo  • 12mo  • 18mo    • age comparison   32 strains   ages shown   Inbred Donahue9 alanine aminotransferase (serum ALT)   [IU/L] 25 strains   age 11wks   B6.PWD consomic Paigen3 alanine aminotransferase (plasma ALT)   [IU/L]   high-fat diet 8wks 8 strains   age 15-19wks   obesity mutants RIKEN-EAD2 alanine aminotransferase (plasma ALT)   [IU/L] 26 strains   age 8wks   wild-derived RBRC   blood — clinical chemistry — enzymes — AST         metabolic panel   Eumorphia1 aspartate aminotransferase (plasma AST; SGOT)   [IU/L] 4 strains   age 12wks   Inbred RIKEN-EAD1 aspartate aminotransferase (plasma AST)   [IU/L] 35 strains   age 8wks   Inbred Rusyn2 aspartate aminotransferase (serum AST), naive   [IU/L] 17 strains   age 7wks   Inbred Rusyn2 aspartate aminotransferase (serum AST) [IU/L]     control and  trichloroethylene         control group:    • 2h    • 8h    • 24h    • time comparison           treated group:    • 2h    • 8h    • 24h    • time comparison   17 strains   age 7wks   Inbred Rusyn2 AST, control vs. treated   trichloroethylene       2h  8h  24h  17 strains   age 7wks   Inbred Threadgill1 aspartate aminotransferase (serum AST) [IU/L]     control and  acetaminophen       • control     post-Rx mg/kg: • 100  • 200  • 300    • comparison   37 strains   age 8-17wks   Inbred Lake1 aspartate aminotransferase (plasma AST)   [mg/dL] 23 strains   age 8wks   B6.A consomic Donahue9 aspartate aminotransferase (serum AST; SGOT)   [IU/L] 25 strains   age 11wks   B6.PWD consomic Svenson3 aspartate aminotransferase (plasma AST)   [mg/dL] 21 strains   age 8wks   B6.PWD consomic RIKEN-EAD2 aspartate aminotransferase (plasma AST)   [IU/L] 26 strains   age 8wks   wild-derived RBRC   blood — clinical chemistry — enzymes — misc         metabolic panel   Eumorphia1 creatine kinase (plasma CK)   [IU/L] 4 strains   age 12wks   Inbred Eumorphia1 lactic acid dehydrogenase (plasma LDH)   [IU/L] 4 strains   age 12wks   Inbred Eumorphia1 plasma alpha-amylase   [IU/L] 4 strains   age 12wks   Inbred Jaxpheno3 creatine kinase (plasma CK) [IU/L]         • age 8wks  • age 16wks    • age comparison   11 strains   ages shown   Inbred RIKEN-EAD1 lactate dehydrogenase (plasma LDH)   [IU/L] 35 strains   age 8wks   Inbred RIKEN-EAD1 plasma amylase   [U/L] 35 strains   age 8wks   Inbred Shockley1 glutamate dehydrogenase (GLDH) [IU/L]     control and  high-fat diet 4wks       • control diet   • high-fat diet   • difference    • comparison   10 strains   age 10-13wks   Inbred Yuan3 lipase (plasma LIP) [U/L]         • 6mo  • 12mo  • 18mo    • age comparison   32 strains   ages shown   Inbred Donahue9 lipase (serum LIP)   [U/L] 25 strains   age 11wks   B6.PWD consomic Donahue9 lactate dehydrogenase (serum LDH)   [U/L] 25 strains   age 11wks   B6.PWD consomic RIKEN-EAD2 lactate dehydrogenase (plasma LDH)   [IU/L] 26 strains   age 8wks   wild-derived RBRC RIKEN-EAD2 plasma amylase   [U/L] 26 strains   age 8wks   wild-derived RBRC   blood — clinical chemistry — gases         metabolic panel   CGDpheno1 dissolved-ionized carbon dioxide (CO2)   [mmol/L] 72 strains   age 10wks   Inbred Yuan3 dissolved-ionized carbon dioxide (CO2) [mmol/L]         • 6mo  • 12mo  • 18mo    • age comparison   31 strains   ages shown   Inbred Donahue9 dissolved-ionized carbon dioxide (serum CO2)   [mmol/L] 25 strains   age 11wks   B6.PWD consomic Chesler2 carbon dioxide (blood CO2)   [mmol/L] 62 strains   age various   CC diallel Chesler3 carbon dioxide (blood CO2)   [mmol/L] age various   CC pre   blood — clinical chemistry — glucose         metabolic panel   CGDpheno1 glucose (plasma GLU, 4h fast)   [mg/dL] 72 strains   age 12wks   Inbred Eumorphia1 glucose (plasma GLU, ??h fast)   [mg/dL] 6 strains   age 12wks   Inbred Jaxpheno3 glucose (plasma GLU, 4h fast) [mg/dL]         • age 8wks  • age 16wks    • age comparison   11 strains   ages shown   Inbred Naggert1 glucose (plasma GLU, 4h fast) [mg/dL]     baseline and  high-fat diet 17wks       • baseline   • after 17wks on diet   • Δchange    • comparison   43 strains   age 7-9wks                 at baseline   Inbred RIKEN-EAD1 glucose (plasma GLU)   [mg/dL] 35 strains   age 8wks   Inbred Schonfeld1 glucose (plasma GLU, non-fasted)   [mg/dL] 10 strains   age 9-13wks   Inbred Shockley1 glucose (GLU) [mg/dL]     control and  high-fat diet 4wks       • control diet   • high-fat diet   • difference    • comparison   10 strains   age 10-13wks   Inbred Lake1 glucose (plasma GLU, 4h fast)   [mg/dL] 23 strains   age 8wks   B6.A consomic Svenson3 glucose (plasma GLU, 4h fast)   [mg/dL] 27 strains   age 8wks   B6.PWD consomic CGDpheno3 glucose (plasma GLU, 4h fast)   [mg/dL] 62 strains   age 8wks   CC diallel Chesler2 glucose (blood GLU)   [mg/dL] 62 strains   age various   CC diallel Chesler2 glucose (blood GLU, overnight fast)   [mg/dL] 62 strains   age various   CC diallel Chesler3 glucose (blood GLU)   [mg/dL] age various   CC pre Chesler3 glucose (blood GLU, overnight fast)   [mg/dL] age various   CC pre RIKEN-EAD2 glucose (plasma GLU)   [mg/dL] 26 strains   age 8wks   wild-derived RBRC   blood — clinical chemistry — glucose — glucose tolerance test         glucose tolerance   Eumorphia3 glucose levels during glucose tolerance test (20% glucose oral, 16h fast) [mg/dL]         minutes: • 0  • 30  • 60  • 90  • 120  • 180    • time comparison   3 strains   age 12wks   Inbred Eumorphia3 glucose levels during glucose tolerance test (20% glucose oral, 16h fast) [mg/dL]         minutes: • 0  • 30  • 60  • 90  • 120  • 180    • time comparison   4 strains   age 24wks   Inbred Eumorphia3 glucose levels during glucose tolerance test (20% glucose oral, 16h fast) [mg/dL]         minutes: • 0  • 30  • 60  • 90  • 120  • 180    • time comparison   4 strains   age 52wks   Inbred Eumorphia3 compare glucose levels by age, glucose tolerance test (20% glucose oral, 16h fast)         minutes: 0  30  60  90  120  180  4 strains   age 52wks   Inbred Schonfeld1 glucose levels during glucose tolerance test (10% glucose i.p., 5h fast) [mg/dL]         • 0min  • 30min  • 60min  • 120min    • time comparison   10 strains   age 9-13wks   Inbred Schonfeld1 glucose levels, area under curve, glucose tolerance test (10% glucose i.p., 5h fast) [AUC]         • 0 to 60min  • 0 to 120min    • time comparison   10 strains   age 9-13wks   Inbred Cheverud1 glucose levels, area under curve, glucose tolerance test (serum GLU, 10% glucose i.p., 4h fast) [AUC]     control and  high-fat diet         age 10wks:   • control diet    • high-fat diet    • comparison           age 20wks:   • control diet    • high-fat diet    • comparison           compare ages:   control diet    high-fat diet  19 strains   ages shown   LGXSM   blood — clinical chemistry — glucose — insulin tolerance test         insulin tolerance   Schonfeld1 glucose levels as percent of baseline, insulin tolerance test (human insulin 0.75 U/kg bw i.p., 5h fast) [%]         • 0min  • 30min  • 60min  • 120min    • time comparison   10 strains   age 9-13wks   Inbred Schonfeld1 glucose levels, area under curve, insulin tolerance test (human insulin 0.75 U/kg bw i.p., 5h fast) [AUC]         • 0 to 60min  • 0 to 120min    • time comparison   10 strains   age 9-13wks   Inbred   blood — clinical chemistry — miscellaneous         metabolic panel   Paigen1 bile salts (plasma)   [µmol/L]   high-fat diet 8wks 43 strains   age 15-19wks   Inbred Schonfeld1 beta-hydroxybutyrate (plasma BHB, 5h fast)   [mM] 10 strains   age 9-13wks   Inbred Tordoff3 blood pH   [pH] 40 strains   age 13-15wks   Inbred Paigen3 bile salts (plasma)   [µmol/L]   high-fat diet 8wks 8 strains   age 15-19wks   obesity mutants   blood — clinical chemistry — miscellaneous         radioimmunoassay   Berndt3 serum vitamin D concentration   [ng/mL] 18 strains   age 11wks   Inbred   blood — clinical chemistry — proteins         metabolic panel   Harrill2 creatinine (serum CREA) [mg/dL]     control and  DB289       • control  • DB289  • difference  34 strains   age 6-8wks   Inbred   blood — clinical chemistry — proteins — albumin         metabolic panel   Eumorphia1 albumin (plasma Alb)   [g/dL] 6 strains   age 12wks   Inbred Jaxpheno3 albumin (Alb) [g/dL]         • age 8wks  • age 16wks    • age comparison   11 strains   ages shown   Inbred RIKEN-EAD1 albumin (plasma Alb)   [g/dL] 35 strains   age 8wks   Inbred Yuan3 albumin (plasma Alb) [g/dL]         • 6mo  • 12mo  • 18mo    • age comparison   32 strains   ages shown   Inbred Donahue9 albumin (serum Alb)   [g/dL] 25 strains   age 11wks   B6.PWD consomic RIKEN-EAD2 albumin (plasma Alb)   [g/dL] 26 strains   age 8wks   wild-derived RBRC   blood — clinical chemistry — proteins — coagulation         coagulation test   Peters1 fibrinogen   [mg/dL] 43 strains   age 10wks   Inbred Svenson3 clotting factors         • AT III   • factor VIII   • fibrinogen  23 strains   age 6wks   B6.PWD consomic   blood — clinical chemistry — proteins — creatinine         metabolic panel   Eumorphia1 plasma creatinine   [mg/dL] 6 strains   age 12wks   Inbred RIKEN-EAD1 plasma creatinine   [mg/dL] 35 strains   age 8wks   Inbred Donahue9 serum creatinine   [mg/dL] 25 strains   age 11wks   B6.PWD consomic Chesler2 creatinine (blood)   [mg/dL] 62 strains   age various   CC diallel Chesler3 creatinine (blood)   [mg/dL] age various   CC pre RIKEN-EAD2 plasma creatinine   [mg/dL] 26 strains   age 8wks   wild-derived RBRC   blood — clinical chemistry — proteins — misc         electrophoresis   Vulpe1 diferric transferrin (plasma), percent of total transferrin   [%] 18 strains   age 8wks   Inbred   blood — clinical chemistry — proteins — misc         ELISA   Tomasini1 fibronectin   [µg/mL] 25 strains   age 9wks   Inbred   blood — clinical chemistry — proteins — misc         HPLC   Rusyn5 homocysteine concentration (plasma) [nmol/mL]   high-fat diet , ethanol       • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred   blood — clinical chemistry — proteins — misc         metabolic panel   Eumorphia1 plasma ferritin   [mg/mL] 4 strains   age 12wks   Inbred Eumorphia1 plasma transferrin   [mg/mL] 4 strains   age 12wks   Inbred   blood — clinical chemistry — proteins — total         metabolic panel   Eumorphia1 total protein (plasma TP)   [g/dL] 6 strains   age 12wks   Inbred Jaxpheno3 total protein (TP) [g/dL]         • age 8wks  • age 16wks    • age comparison   11 strains   ages shown   Inbred RIKEN-EAD1 total protein (plasma TP)   [g/dL] 35 strains   age 8wks   Inbred Yuan3 total protein (plasma TP) [g/dL]         • 6mo  • 12mo  • 18mo    • age comparison   32 strains   ages shown   Inbred Donahue9 total protein (serum TP)   [g/dL] 25 strains   age 11wks   B6.PWD consomic RIKEN-EAD2 total protein (plasma TP)   [g/dL] 26 strains   age 8wks   wild-derived RBRC   blood — clinical chemistry — urea nitrogen         metabolic panel   CGDpheno1 blood urea nitrogen (BUN)   [mg/dL] 72 strains   age 12wks   Inbred Eumorphia1 blood urea nitrogen (BUN)   [mg/dL] 6 strains   age 12wks   Inbred Harrill2 blood urea nitrogen (serum BUN) [mg/dL]     control and  DB289       • control  • DB289  • difference  34 strains   age 6-8wks   Inbred Jaxpheno3 blood urea nitrogen (BUN) [mg/dL]         • age 8wks  • age 16wks    • age comparison   11 strains   ages shown   Inbred RIKEN-EAD1 blood urea nitrogen (plasma BUN)   [mg/dL] 35 strains   age 8wks   Inbred Rusyn2 blood urea nitrogen (serum BUN), naive   [mg/dL] 17 strains   age 7wks   Inbred Rusyn2 blood urea nitrogen (serum BUN) [mg/dL]     control and  trichloroethylene         control group:    • 2h    • 8h    • 24h    • time comparison           treated group:    • 2h    • 8h    • 24h    • time comparison   17 strains   age 7wks   Inbred Rusyn2 blood urea nitrogen (BUN), control vs. treated   trichloroethylene       2h  8h  24h  17 strains   age 7wks   Inbred Shockley1 blood urea nitrogen (BUN) [mg/dL]     control and  high-fat diet 4wks       • control diet   • high-fat diet   • difference    • comparison   10 strains   age 10-13wks   Inbred Threadgill1 blood urea nitrogen (BUN) [mg/dL]     control and  acetaminophen       • control     post-Rx mg/kg: • 100  • 200  • 300    • comparison   36 strains   age 8-17wks   Inbred Yuan3 blood urea nitrogen (plasma BUN) [mg/dL]         • 6mo  • 12mo  • 18mo    • age comparison   31 strains   ages shown   Inbred Donahue9 blood urea nitrogen (serum BUN)   [mg/dL] 25 strains   age 11wks   B6.PWD consomic Svenson3 blood urea nitrogen (plasma BUN)   [mg/dL] 9 strains   age 8wks   B6.PWD consomic Chesler2 blood urea nitrogen (BUN)   [mg/dL] 62 strains   age various   CC diallel Chesler3 blood urea nitrogen (BUN)   [mg/dL] age various   CC pre RIKEN-EAD2 blood urea nitrogen (plasma BUN)   [mg/dL] 26 strains   age 8wks   wild-derived RBRC   blood — clinical chemistry — uric acid         metabolic panel   Eumorphia1 plasma uric acid   [mg/dL] 4 strains   age 12wks   Inbred RIKEN-EAD1 plasma uric acid   [mg/dL] 35 strains   age 8wks   Inbred RIKEN-EAD2 plasma uric acid   [mg/dL] 26 strains   age 8wks   wild-derived RBRC

278 measurements listed.