Home       About             Help       Phenotype data > behavior Options: anxiety attentional performance avoidance balance and coordination exploratory fear conditioning impulsivity involuntary movement learning and memory locomotor activity olfactory social stress reactivity visuospatial learning wildness Methodologies See also:   exercise and endurance   gait analysis   grip strength   ingestive preference   neurosensory   Other related resources of interest Focus:               Investigators, papers, protocols           Ontologies Measurements: Apply tools basic list show overall averages show C57BL/6J averages show variable names verbose descriptions with checkboxes behavior — anxiety         elevated plus maze   Brown1 open arms avoidance index   [n] 14 strains   age 10wks   Inbred Brown1 durations of anxiety related behaviors [s]         • closed arms  • grooming  14 strains   age 10wks   Inbred Brown1 counts of anxiety related behaviors [n]         • closed arms entries  • fecal boli  • head-dips  • stretch attends  • urine puddles  14 strains   age 10wks   Inbred Brown1 closed arms, proportion of total time   [ratio] 14 strains   age 10wks   Inbred Gould2 chronic group: time in closed arms [%]     control and  nicotine 12mg       • control  • nicotine    • comparison   8 strains   age 8-12wks   Inbred Gould2 chronic group: time in open arms [%]     control and  nicotine 12mg       • control  • nicotine    • comparison   8 strains   age 8-12wks   Inbred Gould2 chronic group: time in center [%]     control and  nicotine 12mg       • control  • nicotine    • comparison   8 strains   age 8-12wks   Inbred Gould3 withdrawal group: time in closed arms [%]     control and  nicotine       • control    nicotine dose (mg) • 3  • 6.3  • 12    • comparison   8 strains   age 8-12wks   Inbred Gould3 withdrawal group: time in open arms [%]     control and  nicotine       • control    nicotine dose (mg) • 3  • 6.3  • 12    • comparison   8 strains   age 8-12wks   Inbred Gould3 withdrawal group: time in center [%]     control and  nicotine       • control    nicotine dose (mg) • 3  • 6.3  • 12    • comparison   8 strains   age 8-12wks   Inbred Schalkwyk1 closed arms occupancy         • number of entries  • duration    • comparison   8 strains   age 9-11wks   Inbred Wahlsten1 time spent in two closed arms   [s] 21 strains   age 9wks   Inbred Wahlsten1 number fecal boli, 5 min trial   [n] 21 strains   age 9wks   Inbred Wahlsten1 percent time spent in open arms vs closed   [%] 21 strains   age 9wks   Inbred Spijker2 closed arms occupancy [n]         • entries  12 strains   age 6wks   inbred and BXD   behavior — anxiety         elevated zero maze   Brown1 durations of anxiety related behaviors [s]         • in closed zone  • grooming  13 strains   age 10wks   Inbred Brown1 counts of anxiety related behaviors [n]         • closed zone entries  • fecal boli  • head-dips  • stretch attends  • urine puddles  13 strains   age 10wks   Inbred Brown1 closed zone, proportion of total time   [ratio] 13 strains   age 10wks   Inbred Flaherty1 latency to enter open quadrant   [s] 8 strains   age 8-9wks   Inbred Flaherty1 duration in open quadrants [s]         • total  • q2  • q4  8 strains   age 8-9wks   Inbred Flaherty1 duration in closed quadrants [s]         • total  • q1  • q3  8 strains   age 8-9wks   Inbred Flaherty1 number beam breaks in closed quadrants   [n/s] 8 strains   age 8-9wks   Inbred Flaherty1 percent of time in open quadrants [%]         • both  • q2  • q4  8 strains   age 8-9wks   Inbred Flaherty1 percent of time in closed quadrants [%]         • q1  • q3  8 strains   age 8-9wks   Inbred Flaherty1 total number fecal boli   [n] 8 strains   age 8-9wks   Inbred   behavior — anxiety         hole board test   Lake3 frequency of behavioral displacement [n]         • stretch attends  • grooming episodes  • fecal boli  • urine puddles  23 strains   age 8-9wks   B6.A consomic   behavior — anxiety         light-dark box   Brown1 durations of anxiety related behaviors [s]         • in dark zone  • grooming  14 strains   age 10wks   Inbred Brown1 counts of anxiety related behaviors [n]         • fecal boli  • stretch attends  • urine puddles  14 strains   age 10wks   Inbred Chesler2 anxiety-related behaviors         • latency  • transitions  • defecation  • urination    • comparison   62 strains   age various   CC diallel Chesler3 anxiety-related behaviors         • latency  • transitions  • defecation  • urination    • comparison   age various   CC pre Koide1 time in dark box   [s] 11 strains   age 8-13wks   wild-derived Mishima Koide1 number of transitions between light and dark compartments   [n] 11 strains   age 8-13wks   wild-derived Mishima   behavior — anxiety         observation   Gould2 chronic group: grooming [n]     control and  nicotine 12mg       • control  • nicotine    • comparison   8 strains   age 8-12wks   Inbred Gould2 chronic group: scratching [n]     control and  nicotine 12mg       • control  • nicotine    • comparison   8 strains   age 8-12wks   Inbred Gould2 chronic group: jumping [n]     control and  nicotine 12mg       • control  • nicotine    • comparison   8 strains   age 8-12wks   Inbred Gould3 withdrawal group: grooming [n]     control and  nicotine       • control    nicotine dose (mg) • 3  • 6.3  • 12    • comparison   8 strains   age 8-12wks   Inbred Gould3 withdrawal group: scratching [n]     control and  nicotine       • control    nicotine dose (mg) • 3  • 6.3  • 12    • comparison   8 strains   age 8-12wks   Inbred Gould3 withdrawal group: jumping [n]     control and  nicotine       • control    nicotine dose (mg) • 3  • 6.3  • 12    • comparison   8 strains   age 8-12wks   Inbred   behavior — anxiety         open field test   Brown1 counts of anxiety related behaviors [n]         • fecal boli  • stretch attends  • urine puddles  14 strains   age 10wks   Inbred Brown1 durations of anxiety related behaviors [s]         • freezing  • grooming  14 strains   age 10wks   Inbred Golani1 thigmotaxis endpoints         • near-wall  • curvature  • duration  • incursions  5 strains   age 10wks   Inbred Golani1 measure of center avoidance         • median length  • incursions  • median incursions  • outbound/inbound speeds  5 strains   age 10wks   Inbred Pletcher1 percent of center avoidance (thigmotaxis)   [%] 31 strains   age 7-10wks*   Inbred Wahlsten1 percent of 5 min spent within 10 cm of wall   [%] 21 strains   age 9wks   Inbred Wahlsten1 number of fecal boli, within 5 min trial   [n] 21 strains   age 9wks   Inbred Wiltshire2 OFT center avoidance (thigmotaxis) [%]     control and  fluoxetine       • control  • fluoxetine    • comparison   30 strains   age 10-11wks   Inbred Donahue3 stereotypy (repetitive behavior)         • beam breaks  • episodes  • duration    • comparison   22 strains   age 6-7wks   B6.A consomic Donahue3 rearing         • beam breaks  • episodes  • duration    • comparison   22 strains   age 6-7wks   B6.A consomic Donahue3 thigmotaxis         • duration  • distance traveled    • comparison   22 strains   age 6-7wks   B6.A consomic Donahue4 stereotypy (repetitive behavior)         • beam breaks  • episodes  • duration    • comparison   28 strains   age 6wks   B6.PWD consomic Donahue4 thigmotaxis         • duration  • distance traveled    • comparison   28 strains   age 6wks   B6.PWD consomic Chesler2 thigmotaxis [s]         • latency  • duration    • comparison   62 strains   age various   CC diallel Chesler2 anxiety-related behaviors         • immobility  • defecation  • urination    • comparison   62 strains   age various   CC diallel Chesler3 thigmotaxis [s]         • latency  • duration    • comparison   age various   CC pre Chesler3 anxiety-related behaviors         • immobility  • defecation  • urination    • comparison   age various   CC pre Koide3 anxiety-related behaviors         • freezing  • face washing  • grooming  • stretch attend        • defecation  • urination  • central ambulation  12 strains   age 10wks   wild-derived Mishima   behavior — anxiety         SHIRPA   Jaxpheno7 degree of behavioral inhibition or arousal [score]         • transfer arousal  • freezing  6 strains   age 10wks   Inbred Jaxpheno7 frequency of behavioral displacement (jar) [n]         • defecation  • urination  6 strains   age 10wks   Inbred Jaxpheno7 frequency of behavioral displacement (arena) [n]         • defecation  • urination  6 strains   age 10wks   Inbred Lake2 frequency of behavioral displacement [n]         • defecation  • urination  23 strains   age 8wks   B6.A consomic Lake2 degree of behavioral inhibition or arousal [score]         • transfer arousal  • freezing  23 strains   age 8wks   B6.A consomic Lake2 frequency of behavioral displacement [n]         • defecation  • urination  23 strains   age 8wks   B6.A consomic   behavior — attentional performance         choice serial reaction time task   Spijker1 response [%]           stimulus duration fixed 1s:   • response accuracy    • omission errors          stimulus duration variable:   • response accuracy    • omission errors          compare fixed vs. variable:   response accuracy    omission errors  43 strains   age 8wks   BXD Spijker1 latency of response [s]         • correct  • mode  • variability  • reward    • comparison   43 strains   age 8wks   BXD Spijker1 number of initiated trials (stimulus duration=1s)   [n] 43 strains   age 8wks   BXD   behavior — avoidance — active         avoidance test   Koide1 active avoidance test: correct responses [%]         • day1  • day2  • day3  • day4    • comparison   11 strains   age 8-13wks   wild-derived Mishima   behavior — avoidance — passive         avoidance test   Koide1 passive avoidance test: latency to enter box [s]         • before stimulus   • after stimulus         • next day (learned fear response)    • comparison   11 strains   age 8-13wks   wild-derived Mishima   behavior — balance and coordination         balance beam   Crabbe1 missteps crossing balance beam [n]     control and  ethanol       12.7mm beam: • control    i.p. doses g/kg: • 1.0  • 1.2  • 1.4    • comparison   8 strains   age 8-16wks   Inbred Crabbe1 missteps crossing balance beam [n]     control and  ethanol       15.8mm beam: • control    i.p. doses g/kg: • 1.0  • 1.2  • 1.4    • comparison   8 strains   age 8-16wks   Inbred Crabbe1 missteps crossing balance beam [n]     control and  ethanol       19.0mm beam: • control    i.p. doses g/kg: • 1.0  • 1.2  • 1.4    • comparison   8 strains   age 8-16wks   Inbred Kas1 latency to reach box via a narrow beam   [s] 6 strains   age 5-7mo   Inbred   behavior — balance and coordination         dowel balance test   Crabbe4 latency to fall [s]   ethanol   2g/kg i.p.         T0:   • 9.5mm    • 15.8mm    • comparison           T30:   • 9.5mm    • 15.8mm    • comparison   8 strains   age 12-16wks   Inbred   behavior — balance and coordination         grid test   Crabbe1 grid habituation, distance traveled [cm]     control and  ethanol       • control    i.p. doses g/kg: • 1.5  • 2.0  • 2.5    • comparison   8 strains   age 8-16wks   Inbred Crabbe1 grid habituation, missteps per cm [n/cm]     control and  ethanol       • control    i.p. doses g/kg: • 1.5  • 2.0  • 2.5    • comparison   8 strains   age 8-16wks   Inbred Kas1 inverted grid performance         • latency to fall  • hindlimb movement  • pct hindlimb movement  6 strains   age 5-7mo   Inbred   behavior — balance and coordination         inclined screen test   Crowley1 extrapyramidal side effects (EPS) [s]     baseline and  haloperidol       day: • 0  • 3  • 7  • 30  • 60  • 120    • time comparison   27 strains   age 9-28wks   Inbred   behavior — balance and coordination         parallel rod floor test   Crabbe5 motor incoordination (errors/distance traveled) 1.6mm rod, 6mm space [n/cm]     control and  ethanol       • day1 control   • day2 control   • day3 ethanol    • comparison   8 strains   age 7-14wks   Inbred   behavior — balance and coordination         rotarod   Brown2 latency to fall from accelerating (8 rpm/min) rotarod [s]         day: • 1  • 2  • 3  • 4  • 5  • 6  • 7    • learning comparison   12 strains   age 10-18wks   Inbred Crabbe2 latency to fall from 5 rpm rotarod, 0 min post-injection [s]   diazepam   20 mg/kg       • trial block1  • trial block2    • comparison   15 strains   age 6-7wks   Inbred Crabbe3 fixed speed 3 rpm rotarod (latency to fall) [s]   ethanol       ethanol i.p. g/kg: • 1  • 2  • 3    • comparison   9 strains   age 9-17wks   Inbred Crabbe3 fixed speed 6 rpm rotarod (latency to fall) [s]   ethanol       ethanol i.p. g/kg: • 1  • 2  • 3    • comparison   9 strains   age 9-17wks   Inbred Crabbe3 fixed speed 10 rpm rotarod (latency to fall) [s]   ethanol       ethanol i.p. g/kg: • 1  • 2  • 3    • comparison   9 strains   age 9-17wks   Inbred Crabbe3 accelerating rotarod (latency to fall) - acquisition trials 20 rpm/min [s]         • performance  • improvement  8 strains   age 9-17wks   Inbred Crabbe3 accelerating rotarod (latency to fall) - test day 1 20 rpm/min (ARR1) [s]     baseline and  ethanol various i.p.       • baseline  • ethanol  • Δchange (ethanol effect)  8 strains   age 9-17wks   Inbred Crabbe3 accelerating rotarod (latency to fall) - test day 2 30 rpm/min (ARR1) [s]     baseline and  ethanol various i.p.       • baseline  • ethanol  • Δchange (ethanol effect)  8 strains   age 9-17wks   Inbred Crabbe3 accelerating rotarod (latency to fall) - acquisition trials 20 rpm/min (ARR2) [s]         • performance  • improvement  21 strains   age 9-17wks   Inbred Crabbe3 accelerating rotarod (latency to fall) - test 20 rpm/min (ARR2) [s]     baseline and  ethanol 2g/kg i.p.       • baseline   • ethanol   • Δchange (ethanol effect)   • Δchange (saline control)  21 strains   age 9-17wks   Inbred Jaxpheno7 latency to fall from stationary rotarod during habituation period [s]         • trial1  • trial2  • trial3  • average    • comparison   6 strains   age 10wks   Inbred Jaxpheno7 latency to fall from rotarod at constant 4 rpm [s]         • trial1  • trial2  • trial3  • average    • comparison   6 strains   age 10wks   Inbred Jaxpheno7 latency to fall from accelerating (60 rpm/min) rotarod [s]         • trial1  • trial2  • trial3  • average    • comparison   6 strains   age 10wks   Inbred Jaxpheno7 peak acceleration (0.1 rpm/s) on the rotarod prior to fall [s]         • trial1  • trial2  • trial3  • average    • comparison   6 strains   age 10wks   Inbred Lake3 rotarod habituation, latency to fall from stationary rotarod [s]         • T1  • T2  • T3    • trial comparison   23 strains   age 8-9wks   B6.A consomic Lake3 latency to fall from 4 rpm rotarod [s]         • T1  • T2  • T3    • trial comparison   23 strains   age 8-9wks   B6.A consomic Lake3 latency to fall from accelerating (60 rpm/min) rotarod [s]         • T1  • T2  • T3    • trial comparison   23 strains   age 8-9wks   B6.A consomic   behavior — balance and coordination         vertical wire mesh   Crabbe4 latency to fall from a vertical wire mesh grid 30 min post-injection, screen test   [s]   ethanol   2g/kg i.p. 8 strains   age 9-10wks   Inbred   behavior — balance and coordination — observer-rated ataxia         observation   Metten1 hindlimb splay, 2.75 g/kg injection [score]   ethanol   2.75g/kg i.p.       • 10min after injection  • 30min after    • comparison   9 strains   age 8-11wks   Inbred Metten1 hindlimb splay, 3.0 g/kg injection [score]   ethanol   3.0g/kg i.p.       • 10min after injection  • 30min after    • comparison   9 strains   age 8-11wks   Inbred Metten1 erratic gait, 2.75 g/kg injection [score]   ethanol   2.75g/kg i.p.       • 10min after injection  • 30min after    • comparison   9 strains   age 8-11wks   Inbred Metten1 erratic gait, 3.0 g/kg injection [score]   ethanol   3.0g/kg i.p.       • 10min after injection  • 30min after    • comparison   9 strains   age 8-11wks   Inbred Metten1 compare dose groups, hindlimb splay   ethanol         10min after  30min after  9 strains   age 8-11wks   Inbred Metten1 compare dose groups, eratic gait   ethanol         10min after  30min after  9 strains   age 8-11wks   Inbred   behavior — exploratory         elevated plus maze   Brown1 open arms exploratory behaviors         • duration  • entries  • percent  • ratio  14 strains   age 10wks   Inbred Schalkwyk1 open arms occupancy         • number of entries  • latency  • duration    • comparison   8 strains   age 9-11wks   Inbred Schalkwyk1 duration in center   [s] 8 strains   age 9-11wks   Inbred Wahlsten1 average distance traveled in 1 min   [cm] 21 strains   age 9wks   Inbred Wahlsten1 time spent in zones         • center hub   • two open arms  21 strains   age 9wks   Inbred Spijker2 center occupancy         • entries  • latency    • comparison   12 strains   age 6wks   inbred and BXD Spijker2 open arms occupancy         • duration  • entries    • comparison   12 strains   age 6wks   inbred and BXD   behavior — exploratory         elevated zero maze   Brown1 open zone exploratory behaviors         • duration  • entries  • ratio  13 strains   age 10wks   Inbred   behavior — exploratory         hole board test   Donahue3 nose pokes         • latency  • number  • duration    • comparison   22 strains   age 6-7wks   B6.A consomic Lake3 latency to visit perimeter, 5 min test   [s] 23 strains   age 8-9wks   B6.A consomic Lake3 frequency of exploratory behavior [n]         • arena entries  • head dunks  • hole visits  23 strains   age 8-9wks   B6.A consomic   behavior — exploratory         light-dark box   Brown1 lighted zone exploratory behavior         • duration  • ratio  14 strains   age 10wks   Inbred Brown1 transitions between light and dark zones   [n] 14 strains   age 10wks   Inbred Schalkwyk1 light zone occupancy         • latency  • duration  • transitions    • comparison   8 strains   age 9-11wks   Inbred Wiltshire1 percent duration in light zone, 10 min   [%] 26 strains   age 12-14wks   Inbred Chesler2 light zone occupancy         • duration  • distance  • percent    • comparison   62 strains   age various   CC diallel Chesler3 light zone occupancy         • duration  • distance  • percent    • comparison   age various   CC pre Spijker2 light zone occupancy         • duration  • entries  • latency    • comparison   12 strains   age 6wks   inbred and BXD   behavior — exploratory         monitoring system   Spijker2 home cage latencies [s]         • exploring novel object  • exploring novel object with food           • eating from familiar object  • eating from novel object    • comparison   12 strains   age 6wks   inbred and BXD Spijker2 home cage durations [s]         • exploring novel object  • exploring novel object with food    • comparison   12 strains   age 6wks   inbred and BXD Spijker2 novel cage latencies [s]         • exploring familiar object with food  • eating from familiar object    • comparison   12 strains   age 6wks   inbred and BXD   behavior — exploratory         open field test   Brown1 center square exploratory behavior         • time in center square  • center square entries  14 strains   age 10wks   Inbred Crowley1 center occupancy [%]     baseline and  haloperidol       day: • 0  • 30  • 60  • 120    • time comparison   27 strains   age 9-28wks   Inbred Golani1 measure of center occupancy         • center occupancy  • proportion of incursions  • segment length        • intermediate incursions  • arena-crossings  8 strains   age 10wks   Inbred Golani1 spatial and temporal endpoints         • mid-incursions  • arena-crossings  • path-to-center  • center duration  5 strains   age 10wks   Inbred Schalkwyk1 center square occupancy [s]         • latency  • duration    • comparison   8 strains   age 9-11wks   Inbred Schalkwyk1 center square occupancy in the presence of a novel object         • latency  • duration  • frequency    • comparison   8 strains   age 9-11wks   Inbred Wahlsten1 average distance traveled in 1 min   [cm] 21 strains   age 9wks   Inbred Chesler2 center occupancy [s]         • first min  • total  • distance  • percent    • comparison   62 strains   age various   CC diallel Chesler3 center occupancy [s]         • first min  • total  • distance  • percent    • comparison   age various   CC pre Spijker2 center occupancy         • duration  • entries    • comparison   12 strains   age 6wks   inbred and BXD Koide3 exploratory-related behaviors [n]         • sniffing  • digging  • gnawing  12 strains   age 10wks   wild-derived Mishima   behavior — fear conditioning         fear conditioning chamber   Palmer1 time freezing before exposure to shock, from 30-180 s, day 1   [s] 19 strains   age 7-12wks   B6.A consomic Palmer1 time freezing in context with 24 h history and exposure to shock, from 30-180 s, day 2   [s] 19 strains   age 7-12wks   B6.A consomic Palmer1 time freezing in altered context (no tone) with 48 h history and exposure to shock, from 30-180 s, day 3   [s] 19 strains   age 7-12wks   B6.A consomic Palmer1 time freezing in altered context during 30 s in between 2 tones, day 3   [s] 19 strains   age 7-12wks   B6.A consomic Palmer1 average time freezing during two 30 s tones in altered context, day 3   [s] 19 strains   age 7-12wks   B6.A consomic HMDPpheno4 thigmotaxis [%]           all HMDP:   • pre-stimulus    • post-stimulus    • comparison           inbreds:   • pre-stimulus    • post-stimulus    • comparison           AXB BXA:   • pre-stimulus    • post-stimulus    • comparison           BXD:   • pre-stimulus    • post-stimulus    • comparison           BXH:   • pre-stimulus    • post-stimulus    • comparison   94 strains   age 10wks   HMDP HMDPpheno4 velocity [cm/s]           all HMDP:   • pre-stimulus    • post-stimulus    • comparison           inbreds:   • pre-stimulus    • post-stimulus    • comparison           AXB BXA:   • pre-stimulus    • post-stimulus    • comparison           BXD:   • pre-stimulus    • post-stimulus    • comparison           BXH:   • pre-stimulus    • post-stimulus    • comparison   94 strains   age 10wks   HMDP HMDPpheno4 immobility [%]           all HMDP:   • pre-stimulus    • post-stimulus    • comparison           inbreds:   • pre-stimulus    • post-stimulus    • comparison           AXB BXA:   • pre-stimulus    • post-stimulus    • comparison           BXD:   • pre-stimulus    • post-stimulus    • comparison           BXH:   • pre-stimulus    • post-stimulus    • comparison   94 strains   age 10wks   HMDP HMDPpheno4 post-stimulus activity burst [cm/s]         • all  • inbreds  • AXB BXA  • BXD  • BXH  94 strains   age 10wks   HMDP   behavior — fear conditioning — contextual         fear conditioning chamber   Gould2 acute group, conditioning: immediate fear [%]     control and  nicotine       • control    nicotine dose (mg): • 0.045  • 0.09  • 0.18    • comparison   8 strains   age 8-12wks   Inbred Gould2 acute group, conditioning: contextual fear [%]     control and  nicotine       • control    nicotine dose (mg): • 0.045  • 0.09  • 0.18    • comparison   8 strains   age 8-12wks   Inbred Gould2 chronic group, conditioning: immediate fear [%]     control and  nicotine 12mg       • control  • nicotine    • comparison   8 strains   age 8-12wks   Inbred Gould2 chronic group, conditioning: contextual fear [%]     control and  nicotine 12mg       • control  • nicotine    • comparison   8 strains   age 8-12wks   Inbred Gould3 withdrawal group: conditioning: immediate fear [%]     control and  nicotine       • control    nicotine dose (mg) • 3  • 6.3  • 12    • comparison   8 strains   age 8-12wks   Inbred Gould3 withdrawal group: conditioning: contextual fear [%]     control and  nicotine       • control    nicotine dose (mg) • 3  • 6.3  • 12    • comparison   8 strains   age 8-12wks   Inbred HMDPpheno4 contextual thigmotaxis [%]         • all  • inbreds  • AXB BXA  • BXD  • BXH  94 strains   age 10wks   HMDP HMDPpheno4 contextual velocity [cm/s]         • all  • inbreds  • AXB BXA  • BXD  • BXH  94 strains   age 10wks   HMDP HMDPpheno4 contextual immobility [%]         • all  • inbreds  • AXB BXA  • BXD  • BXH  94 strains   age 10wks   HMDP   behavior — fear conditioning — cued         monitoring system   Gould2 acute group, cued fear: pre-cue [%]     control and  nicotine       • control    nicotine dose (mg): • 0.045  • 0.09  • 0.18    • comparison   8 strains   age 8-12wks   Inbred Gould2 acute group, cued fear: cue [%]     control and  nicotine       • control    nicotine dose (mg): • 0.045  • 0.09  • 0.18    • comparison   8 strains   age 8-12wks   Inbred Gould2 compare pre-cue vs. cue         control    nicotine dose (mg): 0.045  0.09  0.18  8 strains   age 8-12wks   Inbred Gould2 chronic group, cued fear: pre-cue [%]     control and  nicotine 12mg       • control  • nicotine    • comparison   8 strains   age 8-12wks   Inbred Gould2 chronic group, cued fear: cue [%]     control and  nicotine 12mg       • control  • nicotine    • comparison   8 strains   age 8-12wks   Inbred Gould2 compare pre-cue vs. cue         control  nicotine  8 strains   age 8-12wks   Inbred Gould3 withdrawal group: cued fear: pre-cue [%]     control and  nicotine       • control    nicotine dose (mg) • 3  • 6.3  • 12    • comparison   8 strains   age 8-12wks   Inbred Gould3 withdrawal group: cued fear: cue [%]     control and  nicotine       • control    nicotine dose (mg) • 3  • 6.3  • 12    • comparison   8 strains   age 8-12wks   Inbred HMDPpheno4 thigmotaxis [%]           all HMDP:   • pre-cue    • cue    • comparison           inbreds:   • pre-cue    • cue    • comparison           AXB BXA:   • pre-cue    • cue    • comparison           BXD:   • pre-cue    • cue    • comparison           BXH:   • pre-cue    • cue    • comparison   94 strains   age 10wks   HMDP HMDPpheno4 velocity           all HMDP:   • pre-cue    • cue    • comparison           inbreds:   • pre-cue    • cue    • comparison           AXB BXA:   • pre-cue    • cue    • comparison           BXD:   • pre-cue    • cue    • comparison           BXH:   • pre-cue    • cue    • comparison   94 strains   age 10wks   HMDP HMDPpheno4 immobility [%]           all HMDP:   • pre-cue    • cue    • comparison           inbreds:   • pre-cue    • cue    • comparison           AXB BXA:   • pre-cue    • cue    • comparison           BXD:   • pre-cue    • cue    • comparison           BXH:   • pre-cue    • cue    • comparison   94 strains   age 10wks   HMDP   behavior — impulsivity         choice serial reaction time task   Spijker2 responses         • anticipatory  • latency to collect food  • impulsivity    • comparison   12 strains   age 6wks   inbred and BXD   behavior — impulsivity         Go/No-go task   Mitchell1 response         • pre-cue rate  • Go hits  • No-go false alarms    • comparison   15 strains   age 5-7wks   Inbred Mitchell1 latency to respond [s]         • Go cue  • No-go cue    • comparison   15 strains   age 5-7wks   Inbred Mitchell1 measures of efficiency and discrimination [ratio]         • target specificity  • efficiency  • discrimination    • comparison   15 strains   age 5-7wks   Inbred   behavior — impulsivity         operant chamber   Jentsch1 acquisition performance [n]         • initiated trial  • no choice made  • anticipatory    • comparison   53 strains   age 17wks   BXD Jentsch1 acquisition latency [s]         • trial initiation  • correct choice  • reward retrieval    • comparison   53 strains   age 17wks   BXD Jentsch1 reversal performance [n]         • initiated trial  • no choice made  • anticipatory    • comparison   53 strains   age 17wks   BXD Jentsch1 reversal latency [s]         • trial initiation  • correct choice  • reward retrieval    • comparison   53 strains   age 17wks   BXD   behavior — involuntary movement         observation   Crowley1 tongue protrusion [n]     baseline and  haloperidol       day: • 0  • 30  • 60  • 120    • time comparison   27 strains   age 9-28wks   Inbred Crowley1 overt chewing movement [n]     baseline and  haloperidol       day: • 0  • 30  • 60  • 120    • time comparison   27 strains   age 9-28wks   Inbred Crowley1 subtle chewing movement [n]     baseline and  haloperidol       day: • 0  • 30  • 60  • 120    • time comparison   27 strains   age 9-28wks   Inbred Crowley1 jaw tremor [s]     baseline and  haloperidol       day: • 0  • 30  • 60  • 120    • time comparison   27 strains   age 9-28wks   Inbred   behavior — involuntary movement         open field test   Crowley1 repetitive behavior (stereotypy) [n]     baseline and  haloperidol       day: • 0  • 30  • 60  • 120    • time comparison   27 strains   age 9-28wks   Inbred   behavior — involuntary movement         SHIRPA   Jaxpheno7 constant trembling in view-jar (score 0-2)   [score] 6 strains   age 10wks   Inbred Jaxpheno7 short sporadic twitches in view-jar (score 0-2)   [score] 6 strains   age 10wks   Inbred Lake2 constant trembling in view-jar (score 0-2)   [score] 23 strains   age 8wks   B6.A consomic Lake2 short sporadic twitches in view-jar (score 0-2)   [score] 23 strains   age 8wks   B6.A consomic   behavior — involuntary movement — handling-induced convulsion         observation   Metten2 peak handling-induced convulsion score [score]     control and  ethanol aerosolized       • control   • ethanol   • ethanol normalized to controls  15 strains   age 8-15wks   Inbred Metten2 latency to first score used to calculate peak ethanol   [h]   ethanol   aerosolized 15 strains   age 8-15wks   Inbred Metten2 withdrawal severity during 0-25h (area under curve of HIC scores) [AUC]   ethanol   aerosolized       • ethanol   • ethanol normalized to controls  15 strains   age 8-15wks   Inbred   behavior — learning and memory         Morris water maze   Schalkwyk1 latency to reach visible platform   [s] 8 strains   age 9-11wks   Inbred Schalkwyk1 latency to reach hidden platform [s]         trial: • 1  • 2  • 3  • 4  • 5  • 6  • 7    • trial comparison   8 strains   age 9-11wks   Inbred Schalkwyk1 latency to reach reversed platform [s]         • trial 1  • trial 2    • trial comparison   8 strains   age 9-11wks   Inbred   behavior — learning and memory         open field test   Golani1 locational memory and familiarity endpoints         • homebase preference   • homebase visits   • homebase lingering  8 strains   age 10wks   Inbred   behavior — learning and memory         puzzle box   Schalkwyk1 latency to reach goal [s]         • training period  • burrowing task  • plug task    • comparison   8 strains   age 9-11wks   Inbred   behavior — learning and memory — olfactory         olfactory discrimination task   Brown2 percent digging odor pot [%]         • lemon (CS+)  • rose (CS+)  • lemon (CS+) plus rose (CS+)  13 strains   age 10-18wks   Inbred Brown2 total time spent digging   [s] 13 strains   age 10-18wks   Inbred   behavior — locomotor activity         elevated plus maze   Brown1 total activity (line crosses plus rearing, dur=5min))   [n] 14 strains   age 10wks   Inbred Wahlsten1 distance traveled [cm]         during minute: • 1  • 2  • 3  • 4  • 5    • time comparison   21 strains   age 9wks   Inbred Wahlsten1 movement         • % time moving   • speed when moving  21 strains   age 9wks   Inbred Wiltshire1 total locomotor activity, 5 min   [cm] 25 strains   age 12-14wks   Inbred Spijker2 activity [m]         • total distance  12 strains   age 6wks   inbred and BXD   behavior — locomotor activity         elevated zero maze   Brown1 total activity (line crosses plus rearing, dur=5min))   [n] 13 strains   age 10wks   Inbred   behavior — locomotor activity         hole board test   Lake3 frequency of motor activity [n]         • arena rearings  • perimeter rearings  • line crossings  • total activity  23 strains   age 8-9wks   B6.A consomic   behavior — locomotor activity         light-dark box   Brown1 total activity (line crosses plus rearing, dur=5min))   [n] 14 strains   age 10wks   Inbred Koide1 amount of activity (number of beam breaks in 12h period) [n]         • light  • dark    • comparison   11 strains   age 8-13wks   wild-derived Mishima   behavior — locomotor activity         monitoring system   Crabbe2 horizontal distance traveled (immediately to 15 min post-injection) [cm]     baseline and  diazepam       • baseline  doses mg/kg: • 2  • 4  • 8  • 16    • comparison   15 strains   age 6-7wks   Inbred Crabbe2 vertical (rearing) activity (immediately to 15 min post-injection) [n]     baseline and  diazepam       • baseline  doses mg/kg: • 2  • 4  • 8  • 16    • comparison   15 strains   age 6-7wks   Inbred Evsikova1 ambulatory activity (beam break triplets during 24h) [n]         • daily  • light  • dark    • comparison   12 strains   age 6mo   Inbred Evsikova1 rearing activity (beam break triplets during 24h) [n]         • daily  • light  • dark    • comparison   12 strains   age 6mo   Inbred Kas1 home cage activity [cm]         • novelty condition  • day 3    • comparison   6 strains   age 5-7mo   Inbred Mitchell1 ambulatory activity [cm]         • day2 activity  • habituation  15 strains   age 5-7wks   Inbred Mogil2 amount of activity (number of beam breaks in 4h period) [n]         • light   • dark   • dark w/saline injection    • time period comparison   12 strains   age 6-10wks   Inbred Richfield1 horizontal beam breaks           counts (45min session):   • daily avg    • day1    • day2    • day3    • day1-3 comparison           • beam breaks per min    • short-term habituation    • long-term habituation  15 strains   age 7-9wks   Inbred Richfield1 ambulatory activity           counts (45min session):   • daily avg    • day1    • day2    • day3    • day1-3 comparison           • ambulatory activity per min    • short-term habituation    • long-term habituation  15 strains   age 7-9wks   Inbred Richfield1 vertical beam breaks (rearing)           counts (45min session):   • daily avg    • day1    • day2    • day3    • day1-3 comparison           • beam breaks per min    • short-term habituation    • long-term habituation  15 strains   age 7-9wks   Inbred Richfield1 compare habituation for the above tests         short-term habituation  long-term habituation  15 strains   age 7-9wks   Inbred Seburn1 total activity (beam breaks per min)         • daily  • light  • dark    • comparison   16 strains   age 7-9wks   Inbred Seburn1 ambulatory activity (beam breaks per min)         • daily  • light  • dark    • comparison   16 strains   age 7-9wks   Inbred Seburn1 rearing activity (beam breaks per min)         • daily  • light  • dark    • comparison   16 strains   age 7-9wks   Inbred Thomsen1 total activity, test 1 [n]     baseline and  cocaine       • baseline    dose mg/kg i.p.: • 3  • 10  • 18  • 32  • 56    • comparison   15 strains   age 8-10wks   Inbred Thomsen1 total activity, test 2 [n]     baseline and  cocaine       • baseline    dose mg/kg i.p.: • 3  • 10  • 32    • comparison   15 strains   age 8-10wks   Inbred Thomsen1 comparison of test1 vs. test2   cocaine         baseline    dose mg/kg i.p.: 3  10  32  15 strains   age 8-10wks   Inbred Thomsen2 total activity, dose response to D1 agonist [n]     baseline and  R-6-Br-APB       • baseline    dose mg/kg i.p. • 0.03  • 0.32  • 3.2  • 5.6    • comparison   15 strains   age 8-10wks   Inbred Thomsen2 total activity, dose response to D2 agonist [n]     baseline and  quinelorane       • baseline    dose mg/kg i.p. • 0.03  • 0.32  • 3.2  • 5.6    • comparison   15 strains   age 8-10wks   Inbred Thomsen2 comparison of D1 agonist vs. D2 agonist         baseline    dose mg/kg i.p. 0.03  0.32  3.2  5.6  15 strains   age 8-10wks   Inbred   behavior — locomotor activity         open field test   Brown1 total locomotor activity (line crosses plus rearing, dur=5min), day 1   [n] 14 strains   age 10wks   Inbred Crowley1 distance traveled [cm]     baseline and  haloperidol       day: • 0  • 30  • 60  • 120    • time comparison   27 strains   age 9-28wks   Inbred Crowley1 vertical activity [n]     baseline and  haloperidol       day: • 0  • 30  • 60  • 120    • time comparison   27 strains   age 9-28wks   Inbred Golani1 locomotor activity         • distance traveled  • latency to maximum velocity  • change in activity at half-time  8 strains   age 10wks   Inbred Golani1 high-speed motion (progression segment) endpoints         • darting episodes  • distance  • maximal speed        • acceleration  • turn radius  • turn rate  8 strains   age 10wks   Inbred Golani1 low-speed motion (lingering segment) endpoints         • lingering mean  • duration  • special spread  • diversity of motion  8 strains   age 10wks   Inbred Metten1 line crossings, 2.75 g/kg injection [n]     control and  ethanol 2.75g/kg i.p.       • pre-injection  • 10min after injection  • 30min after    • comparison   9 strains   age 8-11wks   Inbred Metten1 line crossings, 3.0 g/kg injection [n]     control and  ethanol 3.0g/kg i.p.       • pre-injection  • 10min after injection  • 30min after    • comparison   9 strains   age 8-11wks   Inbred Metten1 line crossings, compare dose groups     control and  ethanol       pre-injection  10min after injection  30min after  9 strains   age 8-11wks   Inbred Pletcher1 total distance traveled, 7 min   [cm] 31 strains   age 7-10wks*   Inbred Schalkwyk1 total activity         • center  • periphery  • rearing in presence of novel object    • comparison   8 strains   age 9-11wks   Inbred Wahlsten1 distance traveled [cm]         during minute: • 1  • 2  • 3  • 4  • 5    • time comparison   21 strains   age 9wks   Inbred Wahlsten1 average speed over 5 min trial   [cm/sec] 21 strains   age 9wks   Inbred Wiltshire1 total activity [cm]         • activity  • rearing  37 strains   age 12-14wks   Inbred Wiltshire2 OFT distance traveled [cm]     control and  fluoxetine       • control  • fluoxetine    • comparison   30 strains   age 10-11wks   Inbred Donahue3 horizontal activity         • beam breaks  • episodes  • duration    • comparison   22 strains   age 6-7wks   B6.A consomic Donahue3 vertical activity         • beam breaks  • episodes  • duration    • comparison   22 strains   age 6-7wks   B6.A consomic Donahue3 distance traveled [cm]         • center  • total    • comparison   22 strains   age 6-7wks   B6.A consomic Palmer2 distance traveled [cm]     baseline and  methamphetamine       • day1 control   • day2 control   • day3 Rx  22 strains   age 7-16wks   B6.A consomic Palmer2 change in activity from day 1 to day 2 (day1–day2), habituation   [cm] 22 strains   age 7-16wks   B6.A consomic Palmer2 Rx effect on distance traveled [cm]   methamphetamine       • day3–day1   • day3–day2  22 strains   age 7-16wks   B6.A consomic Donahue4 horizontal acitivity         • beam breaks  • episodes  • duration    • comparison   28 strains   age 6wks   B6.PWD consomic Donahue4 vertical activity         • beam breaks  • episodes  • duration    • comparison   28 strains   age 6wks   B6.PWD consomic Donahue4 distance traveled [cm]         • center  • total    • comparison   28 strains   age 6wks   B6.PWD consomic Chesler2 locomotor activity [cm]         • first 3 min  • total  • transitions    • comparison   62 strains   age various   CC diallel Chesler3 locomotor activity [cm]         • first 3 min  • total  • transitions    • comparison   age various   CC pre Spijker2 activity         • total distance  • stops  • acceleration        • distance per progression  • number of progressions  • duration of progression        • lingering episode    • comparison   12 strains   age 6wks   inbred and BXD Koide3 locomotor activity [n]         • transitions  • ambulation  • rearing  • leaning  • jumping  • pausing    • comparison   12 strains   age 10wks   wild-derived Mishima   behavior — locomotor activity         parallel rod floor test   Crabbe5 distance traveled, 1.6mm rod, 6mm space [cm]     control and  ethanol       • day1 control   • day2 control   • day3 ethanol    • comparison   8 strains   age 8-10wks   Inbred   behavior — locomotor activity         SHIRPA   Jaxpheno7 spontaneous activity level in view-jar (score 0-3)   [score] 6 strains   age 10wks   Inbred Lake2 spontaneous activity level in view-jar (score 0-3)   [score] 23 strains   age 8wks   B6.A consomic   behavior — social — preference for social novelty test         operant chamber   Moy1 duration of time spent [s]         • with former novel mouse  • with second novel mouse  • in homebase    • comparison   17 strains   age 6-7wks   Inbred Moy1 exploratory sniffing in cage with: [s]         • former novel mouse  • second novel mouse    • comparison   17 strains   age 6-7wks   Inbred Moy1 repeat entry to chamber: [n]         • with former novel mouse  • with second novel mouse    • comparison   17 strains   age 6-7wks   Inbred   behavior — social — sociability test         operant chamber   Moy1 duration of time spent [s]         • with novel mouse  • with novel object  • in homebase    • comparison   17 strains   age 6-7wks   Inbred Moy1 exploratory sniffing in cage with: [s]         • novel mouse  • novel object    • comparison   17 strains   age 6-7wks   Inbred Moy1 repeat entry to chamber: [n]         • with novel mouse  • with novel object    • comparison   17 strains   age 6-7wks   Inbred   behavior — stress reactivity         forced swim test   Gould1 duration of immobility [s]     control and  lithium       lithium dose [mg/kg]: • 0(saline)  • 200  • 300  • 400    • comparison   11 strains   age 7-8wks   Inbred   behavior — stress reactivity         light-dark box   Gershenfeld1 number of transitions between light and dark compartments in 10 min [n]     baseline and  imipramine       • baseline   • imipramine 30mg/kg    • comparison   12 strains   age 5-10wks   Inbred   behavior — stress reactivity         open field test   Gershenfeld1 distance traveled in 5 min [cm]     baseline and  imipramine       • baseline   • imipramine 30mg/kg    • comparison   12 strains   age 5-10wks   Inbred Gershenfeld1 vertical movements (rearing) in 15 min [n]     baseline and  imipramine       • baseline   • imipramine 30mg/kg    • comparison   12 strains   age 5-10wks   Inbred Gershenfeld1 average center time, 2 trials [s]     baseline and  imipramine       • baseline   • imipramine 30mg/kg    • comparison   12 strains   age 5-10wks   Inbred Gershenfeld1 number of fecal boli in 15 min [n]     baseline and  imipramine       • baseline   • imipramine 30mg/kg    • comparison   12 strains   age 5-10wks   Inbred   behavior — stress reactivity         tail suspension test   Gershenfeld1 TST duration of immobility, effect of saline injection on control group [s]         • before injection   • after injection    • comparison   12 strains   age 5-10wks   Inbred Gershenfeld1 TST duration of immobility, treatment group [s]     baseline and  imipramine       • baseline   • imipramine 30mg/kg    • comparison   12 strains   age 5-10wks   Inbred Gershenfeld1 TST immobility percentage, imipramine vs. saline   [%]   imipramine   12 strains   age 5-10wks   Inbred Pletcher1 TST immobility percentage   [%] 30 strains   age 7-10wks*   Inbred Schalkwyk1 TST duration of immobility [s]         • trial 1  • trial 2    • trial comparison   8 strains   age 9-11wks   Inbred Wiltshire2 TST duration of immobility [%]     control and  fluoxetine       • control  • fluoxetine    • comparison   30 strains   age 9-10wks   Inbred   behavior — visuospatial learning         Barnes circular maze   Brown2 acquisition training mean errors [n]         • day1  • day4  13 strains   age 10-18wks   Inbred Brown2 reversal training mean errors [n]         • day1  • day4  13 strains   age 10-18wks   Inbred Brown2 acquisition training mean latency to escape [s]         • day1  • day4  13 strains   age 10-18wks   Inbred Brown2 reversal training mean latency to escape [s]         • day1  • day4  13 strains   age 10-18wks   Inbred Brown2 probe trial correct quadrant         • entries  • duration  • % correct  13 strains   age 10-18wks   Inbred   behavior — visuospatial learning         Morris water maze   Brown2 mean distance traveled to find hidden platform, day 3 [cm]         • acquisition training  • reversal training    • comparison   14 strains   age 10-18wks   Inbred Brown2 mean velocity, day 3 [cm/s]         • acquisition training  • reversal training    • comparison   14 strains   age 10-18wks   Inbred Brown2 mean latency to find hidden platform, day 3 [s]         • acquisition training  • reversal training    • comparison   14 strains   age 10-18wks   Inbred Brown2 probe trial, correct quadrant         • duration  • % time  14 strains   age 10-18wks   Inbred Brown2 mean time within pool edge, across all aquistion and reversal trials   [s] 14 strains   age 10-18wks   Inbred Brown2 mean latency to find visible platform   [s] 14 strains   age 10-18wks   Inbred   behavior — visuospatial learning — visual acuity         visual water box   Brown2 percent correct [%]         grating threshold: • 0.17 (low)  • 0.32  • 0.64 (high)  14 strains   age 10-18wks   Inbred Brown2 latency to reach cued platform [s]         grating threshold: • 0.17 (low)  • 0.32  • 0.64 (high)  • overall mean  14 strains   age 10-18wks   Inbred   behavior — visuospatial learning — visual discrimination         visual water box   Brown2 percent correct, 0.17 grating threshold (low), day 8 [%]         • visual detection  • pattern discrimination  14 strains   age 10-18wks   Inbred Brown2 mean latency to reach cued platform, 0.17 grating threshold (low), day 8 [s]         • visual detection  • pattern discrimination  14 strains   age 10-18wks   Inbred   behavior — wildness         observation   Wahlsten2 number of tests with: [score]         • sqeaks   • bites   • escapes   • no wildness events  21 strains   age 10-12wks   Inbred Wahlsten2 overall mean ratings [score]         • capture rating  • hold rating  21 strains   age 10-12wks   Inbred Wahlsten2 wildness rating during: [score]         • capture and hold   • OF and EPM   • rotarod   • water escape   • weighing  21 strains   age 10-12wks   Inbred Chesler2 wildness rating [score]         • capture  • hold  • total    • comparison   62 strains   age various   CC diallel Chesler3 wildness rating [score]         • capture  • hold  • total    • comparison   age various   CC pre   behavior — wildness         SHIRPA   Jaxpheno7 aggressive behavior [score]         • provoked biting  • irritability  • aggression  • vocalization  • finger approach  6 strains   age 10wks   Inbred Lake2 aggressive behavior [score]         • provoked biting  • irritability  • aggression  • vocalization  23 strains   age 8wks   B6.A consomic 827 measurements listed.

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