Home       About             Help       Phenotype data > DBA/2J strain > behavior Options: anxiety attentional performance balance and coordination exploratory fear conditioning impulsivity involuntary movement learning and memory locomotor activity olfactory social stress reactivity visuospatial learning wildness Methodologies Focus: Measurements: About these DBA/2J averages (♀ ♂) Exit DBA/2J mode behavior — anxiety         elevated plus maze   Brown1 open arms avoidance index   [n] ...... 0.741   0.704   14 strains   age 10wks   Inbred Brown1 durations of anxiety related behaviors [s]         • closed arms  ...... 172   137 ▲         • grooming  ...... 30.6 ▲▲   9.29 ▲         14 strains   age 10wks   Inbred Brown1 counts of anxiety related behaviors [n]         • closed arms entries  ...... 8.42   11.4         • fecal boli  ...... 3.85 ▲   2.77         • head-dips  ...... 8.62   10.2 ▼         • stretch attends  ...... 5.31   4.00         • urine puddles  ...... 1.54   1.62         14 strains   age 10wks   Inbred Brown1 closed arms, proportion of total time   [ratio] ...... 0.576   0.460 ▲   14 strains   age 10wks   Inbred Gould2 chronic group: time in closed arms [%]     control and  nicotine 12mg       • control  ...... 65.2 ▲         • nicotine  ...... 62.5 ▲           • comparison   8 strains   age 8-12wks   Inbred Gould2 chronic group: time in open arms [%]     control and  nicotine 12mg       • control  ...... 14.6 ▼         • nicotine  ...... 18.2 ▼           • comparison   8 strains   age 8-12wks   Inbred Gould2 chronic group: time in center [%]     control and  nicotine 12mg       • control  ...... 20.8         • nicotine  ...... 18.7           • comparison   8 strains   age 8-12wks   Inbred Gould3 withdrawal group: time in closed arms [%]     control and  nicotine       • control  ...... 57.3 ▲         nicotine dose (mg)             • 3  ...... 65.8 ▲               • 6.3  ...... 55.1 ▲               • 12  ...... 71.6 ▲                 • comparison   8 strains   age 8-12wks   Inbred Gould3 withdrawal group: time in open arms [%]     control and  nicotine       • control  ...... 21.3 ▼         nicotine dose (mg)             • 3  ...... 17.5 ▼               • 6.3  ...... 15.2 ▼               • 12  ...... 15.4 ▼                 • comparison   8 strains   age 8-12wks   Inbred Gould3 withdrawal group: time in center [%]     control and  nicotine       • control  ...... 21.6         nicotine dose (mg)             • 3  ...... 16.9               • 6.3  ...... 30.0               • 12  ...... 13.3                 • comparison   8 strains   age 8-12wks   Inbred Schalkwyk1 closed arms occupancy         • number of entries  ...... 10.8         • duration  ...... 188 ▲           • comparison   8 strains   age 9-11wks   Inbred Wahlsten1 time spent in two closed arms   [s] ...... 42.3 ▲   40.2 ▲   21 strains   age 9wks   Inbred Wahlsten1 number fecal boli, 5 min trial   [n] ...... 2.50   2.00   21 strains   age 9wks   Inbred Wahlsten1 percent time spent in open arms vs closed   [%] ...... 15.9 ▼   17.8 ▼   21 strains   age 9wks   Inbred Spijker2 closed arms occupancy [n]         • entries  ...... 19.9         12 strains   age 6wks   inbred and BXD   behavior — anxiety         elevated zero maze   Brown1 durations of anxiety related behaviors [s]         • in closed zone  ...... 251 ▲   206         • grooming  ...... 0.393   0.247         13 strains   age 10wks   Inbred Brown1 counts of anxiety related behaviors [n]         • closed zone entries  ...... 7.17   11.5         • fecal boli  ...... 1.00   1.80         • head-dips  ...... 6.50 ▼   11.4         • stretch attends  ...... 13.8   8.70         • urine puddles  ...... 0.667   1.30         13 strains   age 10wks   Inbred Brown1 closed zone, proportion of total time   [ratio] ...... 0.840 ▲   0.689   13 strains   age 10wks   Inbred Flaherty1 latency to enter open quadrant   [s] ...... 107   90.5 ▲   8 strains   age 8-9wks   Inbred Flaherty1 duration in open quadrants [s]         • total  ...... 24.6   30.1         • q2  ...... 9.82 ▼   15.7         • q4  ...... 14.8   14.4         8 strains   age 8-9wks   Inbred Flaherty1 duration in closed quadrants [s]         • total  ...... 275   270         • q1  ...... 229   225         • q3  ...... 46.7   44.6         8 strains   age 8-9wks   Inbred Flaherty1 number beam breaks in closed quadrants   [n/s] ...... 306 ▼   389   8 strains   age 8-9wks   Inbred Flaherty1 percent of time in open quadrants [%]         • both  ...... 8.21   10.0         • q2  ...... 3.27 ▼   5.23         • q4  ...... 4.94   4.80         8 strains   age 8-9wks   Inbred Flaherty1 percent of time in closed quadrants [%]         • q1  ...... 76.2   75.1         • q3  ...... 15.6   14.9         8 strains   age 8-9wks   Inbred Flaherty1 total number fecal boli   [n] ...... 4.55   3.50   8 strains   age 8-9wks   Inbred   behavior — anxiety         light-dark box   Brown1 durations of anxiety related behaviors [s]         • in dark zone  ...... 244   212         • grooming  ...... 12.9 ▲   5.73         14 strains   age 10wks   Inbred Brown1 counts of anxiety related behaviors [n]         • fecal boli  ...... 3.57   3.31         • stretch attends  ...... 5.50   3.31         • urine puddles  ...... 1.07   1.08         14 strains   age 10wks   Inbred   behavior — anxiety         observation   Gould2 chronic group: grooming [n]     control and  nicotine 12mg       • control  ...... 3.70         • nicotine  ...... 4.10           • comparison   8 strains   age 8-12wks   Inbred Gould2 chronic group: scratching [n]     control and  nicotine 12mg       • control  ...... 0.700         • nicotine  ...... 0.500           • comparison   8 strains   age 8-12wks   Inbred Gould2 chronic group: jumping [n]     control and  nicotine 12mg       • control  ...... 0.100         • nicotine  ...... 0           • comparison   8 strains   age 8-12wks   Inbred Gould3 withdrawal group: grooming [n]     control and  nicotine       • control  ...... 6.25 ▲         nicotine dose (mg)             • 3  ...... 4.60 ▲▲               • 6.3  ...... 5.70 ▲               • 12  ...... 6.00 ▲                 • comparison   8 strains   age 8-12wks   Inbred Gould3 withdrawal group: scratching [n]     control and  nicotine       • control  ...... 3.00 ▲         nicotine dose (mg)             • 3  ...... 0.900               • 6.3  ...... 3.80 ▲               • 12  ...... 2.50 ▲                 • comparison   8 strains   age 8-12wks   Inbred Gould3 withdrawal group: jumping [n]     control and  nicotine       • control  ...... 0.167         nicotine dose (mg)             • 3  ...... 0.100               • 6.3  ...... 0.200               • 12  ...... 0                 • comparison   8 strains   age 8-12wks   Inbred   behavior — anxiety         open field test   Brown1 counts of anxiety related behaviors [n]         • fecal boli  ...... 1.93   1.77         • stretch attends  ...... 3.93   1.77         • urine puddles  ...... 1.29   1.15         14 strains   age 10wks   Inbred Brown1 durations of anxiety related behaviors [s]         • freezing  ...... 0.388   0.495         • grooming  ...... 12.7 ▲   6.21         14 strains   age 10wks   Inbred Golani1 thigmotaxis endpoints         • near-wall  ...... 39.5 ▼         • curvature  ...... 4.03 ▼         • duration  ...... 1.42         • incursions  ...... 14.0         5 strains   age 10wks   Inbred Golani1 measure of center avoidance         • median length  ...... 20.3         • incursions  ...... 62.4 ▼         • median incursions  ...... 5.06 ▼         • outbound/inbound speeds  ...... 0.839 ▼         5 strains   age 10wks   Inbred Pletcher1 percent of center avoidance (thigmotaxis)   [%] ...... 96.0 ▲   31 strains   age 7-10wks*   Inbred Wahlsten1 percent of 5 min spent within 10 cm of wall   [%] ...... 83.8   83.7   21 strains   age 9wks   Inbred Wahlsten1 number of fecal boli, within 5 min trial   [n] ...... 0.800 ▼   1.88   21 strains   age 9wks   Inbred Wiltshire2 OFT center avoidance (thigmotaxis) [%]     control and  fluoxetine       • control  ...... 94.4 ▲         • fluoxetine  ...... 97.4 ▲           • comparison   30 strains   age 10-11wks   Inbred   behavior — anxiety         SHIRPA   Jaxpheno7 degree of behavioral inhibition or arousal [score]         • transfer arousal  ...... 1.27         • freezing  ...... 0.545         6 strains   age 10wks   Inbred Jaxpheno7 frequency of behavioral displacement (jar) [n]         • defecation  ...... 0.0909         • urination  ...... 0         6 strains   age 10wks   Inbred Jaxpheno7 frequency of behavioral displacement (arena) [n]         • defecation  ...... 1.45         • urination  ...... 0         6 strains   age 10wks   Inbred   behavior — attentional performance         choice serial reaction time task   Spijker1 response [%]         stimulus duration fixed 1s:             • response accuracy  ...... 84.0               • omission errors  ...... 49.1                     stimulus duration variable:             • response accuracy  ...... 71.7               • omission errors  ...... 52.6                     compare fixed vs. variable:             response accuracy  ......             omission errors  ......             43 strains   age 8wks   BXD Spijker1 latency of response [s]         • correct  ...... 0.917         • mode  ...... 0.655         • variability  ...... 0.569         • reward  ...... 2.52           • comparison   43 strains   age 8wks   BXD Spijker1 number of initiated trials (stimulus duration=1s)   [n] ...... 57.6   43 strains   age 8wks   BXD   behavior — balance and coordination         balance beam   Crabbe1 missteps crossing balance beam [n]     control and  ethanol       12.7mm beam:             • control  ...... 1.67 (N=3)   0.333 (N=3) ▼               i.p. doses g/kg:             • 1.0  ...... 1.83   3.00               • 1.2  ...... 1.29 ▼   3.40               • 1.4  ...... 7.14 ▲   4.20                 • comparison   8 strains   age 8-16wks   Inbred Crabbe1 missteps crossing balance beam [n]     control and  ethanol       15.8mm beam:             • control  ...... 0.667 (N=3)   0.333 (N=3)               i.p. doses g/kg:             • 1.0  ...... 1.83   1.79               • 1.2  ...... 1.36   3.17               • 1.4  ...... 3.69   3.10                 • comparison   8 strains   age 8-16wks   Inbred Crabbe1 missteps crossing balance beam [n]     control and  ethanol       19.0mm beam:             • control  ...... 1.00 (N=3) ▲   1.67 (N=3) ▲               i.p. doses g/kg:             • 1.0  ...... 0.835 (N=4)   0.402 ▼               • 1.2  ...... 0   0.168 (N=4) ▼               • 1.4  ...... 0.668   1.42 (N=4)                 • comparison   8 strains   age 8-16wks   Inbred Kas1 latency to reach box via a narrow beam   [s] ...... 5.00   6 strains   age 5-7mo   Inbred   behavior — balance and coordination         dowel balance test   Crabbe4 latency to fall [s]   ethanol   2g/kg i.p.       T0:             • 9.5mm  ...... 86.2 (N=4)   62.0 (N=4)               • 15.8mm  ...... 102 (N=4)   101 (N=3)                 • comparison         T30:             • 9.5mm  ...... 129 (N=4) ▲   15.2 (N=4)               • 15.8mm  ...... 240 (N=4) ▲   10.0 (N=3)                 • comparison   8 strains   age 12-16wks   Inbred   behavior — balance and coordination         grid test   Crabbe1 grid habituation, distance traveled [cm]     control and  ethanol       • control  ...... 618   653         i.p. doses g/kg:             • 1.5  ...... 1472 (N=4)   1287 (N=4) ▲               • 2.0  ...... 1118 (N=4)   1228 (N=4)               • 2.5  ...... 1861 (N=4) ▲   1466 (N=4) ▲                 • comparison   8 strains   age 8-16wks   Inbred Crabbe1 grid habituation, missteps per cm [n/cm]     control and  ethanol       • control  ...... 0.00717   0.00475         i.p. doses g/kg:             • 1.5  ...... 0.0777 (N=4)   0.0993 (N=4)               • 2.0  ...... 0.196 (N=4)   0.290 (N=4)               • 2.5  ...... 0.383 (N=4)   0.478 (N=4) ▲                 • comparison   8 strains   age 8-16wks   Inbred Kas1 inverted grid performance         • latency to fall  ...... 126 ▼         • hindlimb movement  ...... 46.8         • pct hindlimb movement  ...... 66.3         6 strains   age 5-7mo   Inbred   behavior — balance and coordination         inclined screen test   Crowley1 extrapyramidal side effects (EPS) [s]     baseline and  haloperidol       day:             • 0  ...... 3.22               • 3  ...... 5.78               • 7  ...... 19.1               • 30  ...... 10.0               • 60  ...... 7.78               • 120  ...... 10.7                 • time comparison   27 strains   age 9-28wks   Inbred   behavior — balance and coordination         parallel rod floor test   Crabbe5 motor incoordination (errors/distance traveled) 1.6mm rod, 6mm space [n/cm]     control and  ethanol       • day1 control  ...... 2.00   2.50 (N=4)         • day2 control  ...... 2.82   1.92 (N=4)         • day3 ethanol  ...... 16.9 ▼   20.8 (N=4)           • comparison   8 strains   age 7-14wks   Inbred   behavior — balance and coordination         rotarod   Brown2 latency to fall from accelerating (8 rpm/min) rotarod [s]         day:             • 1  ...... 67.5   66.5               • 2  ...... 95.9   77.4               • 3  ...... 108   90.3               • 4  ...... 112   99.3               • 5  ...... 119   107               • 6  ...... 122   109               • 7  ...... 136   117                 • learning comparison   12 strains   age 10-18wks   Inbred Crabbe2 latency to fall from 5 rpm rotarod, 0 min post-injection [s]   diazepam   20 mg/kg       • trial block1  ...... 22.9 ▼         • trial block2  ...... 131           • comparison   15 strains   age 6-7wks   Inbred Crabbe3 fixed speed 3 rpm rotarod (latency to fall) [s]   ethanol       ethanol i.p. g/kg:             • 1  ...... 147 (N=4)   117 (N=4) ▼               • 2  ...... 75.6 (N=4)   62.9 (N=4) ▼               • 3  ...... 91.1 (N=4)   36.0 (N=4) ▼                 • comparison   9 strains   age 9-17wks   Inbred Crabbe3 fixed speed 6 rpm rotarod (latency to fall) [s]   ethanol       ethanol i.p. g/kg:             • 1  ...... 180 (N=1) ▲   91.2 (N=3)               • 2  ...... 122 (N=2)   72.6 (N=2)               • 3  ...... 51.9 (N=4)   30.3 (N=2) ▼                 • comparison   9 strains   age 9-17wks   Inbred Crabbe3 fixed speed 10 rpm rotarod (latency to fall) [s]   ethanol       ethanol i.p. g/kg:             • 1  ...... 64.5 (N=2)               • 2  ...... 79.6 (N=1)   54.0 (N=2)               • 3  ...... 79.7 (N=2) ▲                 • comparison   9 strains   age 9-17wks   Inbred Crabbe3 accelerating rotarod (latency to fall) - acquisition trials 20 rpm/min [s]         • performance  ...... 26.4   24.3         • improvement  ...... 4.40   2.86         8 strains   age 9-17wks   Inbred Crabbe3 accelerating rotarod (latency to fall) - test day 1 20 rpm/min (ARR1) [s]     baseline and  ethanol various i.p.       • baseline  ...... 17.7   17.4 ▼         • ethanol  ...... 21.5   20.2         • Δchange (ethanol effect)  ...... 3.73   5.63         8 strains   age 9-17wks   Inbred Crabbe3 accelerating rotarod (latency to fall) - test day 2 30 rpm/min (ARR1) [s]     baseline and  ethanol various i.p.       • baseline  ...... 13.9   13.2 ▼         • ethanol  ...... 17.5 (N=4)   22.6         • Δchange (ethanol effect)  ...... 4.40 (N=4)   10.3         8 strains   age 9-17wks   Inbred Crabbe3 accelerating rotarod (latency to fall) - acquisition trials 20 rpm/min (ARR2) [s]         • performance  ...... 30.7 ▼   19.6 ▼         • improvement  ...... 16.6   6.62 ▼         21 strains   age 9-17wks   Inbred Crabbe3 accelerating rotarod (latency to fall) - test 20 rpm/min (ARR2) [s]     baseline and  ethanol 2g/kg i.p.       • baseline  ...... 33.9 ▼   29.6 ▼         • ethanol  ...... 37.8   30.7         • Δchange (ethanol effect)  ...... 3.90   1.12 ▲         • Δchange (saline control)  ...... 10.8   7.00         21 strains   age 9-17wks   Inbred Jaxpheno7 latency to fall from stationary rotarod during habituation period [s]         • trial1  ...... 51.0         • trial2  ...... 60.0         • trial3  ...... 60.0         • average  ...... 54.8           • comparison   6 strains   age 10wks   Inbred Jaxpheno7 latency to fall from rotarod at constant 4 rpm [s]         • trial1  ...... 46.3 ▲         • trial2  ...... 34.4         • trial3  ...... 40.6         • average  ...... 44.5 ▲           • comparison   6 strains   age 10wks   Inbred Jaxpheno7 latency to fall from accelerating (60 rpm/min) rotarod [s]         • trial1  ...... 31.3         • trial2  ...... 40.8         • trial3  ...... 49.5         • average  ...... 40.5           • comparison   6 strains   age 10wks   Inbred Jaxpheno7 peak acceleration (0.1 rpm/s) on the rotarod prior to fall [s]         • trial1  ...... 7.13         • trial2  ...... 8.08         • trial3  ...... 8.95         • average  ...... 8.05           • comparison   6 strains   age 10wks   Inbred   behavior — balance and coordination         vertical wire mesh   Crabbe4 latency to fall from a vertical wire mesh grid 30 min post-injection, screen test   [s] ...... 129 (N=4)   125 (N=4)     ethanol   2g/kg i.p. 8 strains   age 9-10wks   Inbred   behavior — balance and coordination — observer-rated ataxia         observation   Metten1 hindlimb splay, 2.75 g/kg injection [score]   ethanol   2.75g/kg i.p.       • 10min after injection  ...... 2.57   3.00 (N=3)         • 30min after  ...... 0.714   2.33 (N=3)           • comparison   9 strains   age 8-11wks   Inbred Metten1 hindlimb splay, 3.0 g/kg injection [score]   ethanol   3.0g/kg i.p.       • 10min after injection  ...... 3.50   2.25 (N=4)         • 30min after  ...... 1.88   2.00 (N=3)           • comparison   9 strains   age 8-11wks   Inbred Metten1 erratic gait, 2.75 g/kg injection [score]   ethanol   2.75g/kg i.p.       • 10min after injection  ...... 0.429   0 (N=3)         • 30min after  ...... 0.429   0 (N=3)           • comparison   9 strains   age 8-11wks   Inbred Metten1 erratic gait, 3.0 g/kg injection [score]   ethanol   3.0g/kg i.p.       • 10min after injection  ...... 1.25   0.250 (N=4)         • 30min after  ...... 0.250   0 (N=3) ▼           • comparison   9 strains   age 8-11wks   Inbred Metten1 compare dose groups, hindlimb splay   ethanol         10min after        30min after        9 strains   age 8-11wks   Inbred Metten1 compare dose groups, eratic gait   ethanol         10min after        30min after        9 strains   age 8-11wks   Inbred   behavior — exploratory         elevated plus maze   Brown1 open arms exploratory behaviors         • duration  ...... 82.4   104         • entries  ...... 9.17   11.1         • percent  ...... 24.1   24.6         • ratio  ...... 0.276   0.347         14 strains   age 10wks   Inbred Schalkwyk1 open arms occupancy         • number of entries  ...... 3.09         • latency  ...... 171         • duration  ...... 21.7           • comparison   8 strains   age 9-11wks   Inbred Schalkwyk1 duration in center   [s] ...... 90.0   8 strains   age 9-11wks   Inbred Wahlsten1 average distance traveled in 1 min   [cm] ...... 175   177   21 strains   age 9wks   Inbred Wahlsten1 time spent in zones         • center hub  ...... 9.85 ▼   10.8 ▼         • two open arms  ...... 7.85 ▼   9.01 ▼         21 strains   age 9wks   Inbred Spijker2 center occupancy         • entries  ...... 26.6         • latency  ...... 2.20           • comparison   12 strains   age 6wks   inbred and BXD Spijker2 open arms occupancy         • duration  ...... 11.4         • entries  ...... 7.30           • comparison   12 strains   age 6wks   inbred and BXD   behavior — exploratory         elevated zero maze   Brown1 open zone exploratory behaviors         • duration  ...... 48.0 ▼   93.2         • entries  ...... 6.67   11.0         • ratio  ...... 0.160 ▼   0.311         13 strains   age 10wks   Inbred   behavior — exploratory         light-dark box   Brown1 lighted zone exploratory behavior         • duration  ...... 54.6   87.7         • ratio  ...... 0.183   0.293         14 strains   age 10wks   Inbred Brown1 transitions between light and dark zones   [n] ...... 8.07   15.6   14 strains   age 10wks   Inbred Schalkwyk1 light zone occupancy         • latency  ...... 103         • duration  ...... 60.5         • transitions  ...... 9.00           • comparison   8 strains   age 9-11wks   Inbred Wiltshire1 percent duration in light zone, 10 min   [%] ...... 2.17 (N=4)   4.50 (N=4)   26 strains   age 12-14wks   Inbred Spijker2 light zone occupancy         • duration  ...... 92.6         • entries  ...... 23.0         • latency  ...... 5.08           • comparison   12 strains   age 6wks   inbred and BXD   behavior — exploratory         monitoring system   Spijker2 home cage latencies [s]         • exploring novel object  ...... 58.2         • exploring novel object with food  ...... 12.2         • eating from familiar object  ...... 42.2         • eating from novel object  ...... 102           • comparison   12 strains   age 6wks   inbred and BXD Spijker2 home cage durations [s]         • exploring novel object  ...... 16.6         • exploring novel object with food  ...... 14.3           • comparison   12 strains   age 6wks   inbred and BXD Spijker2 novel cage latencies [s]         • exploring familiar object with food  ...... 32.4         • eating from familiar object  ...... 146           • comparison   12 strains   age 6wks   inbred and BXD   behavior — exploratory         open field test   Brown1 center square exploratory behavior         • time in center square  ...... 1.35 ▼   3.05         • center square entries  ...... 1.21   2.77         14 strains   age 10wks   Inbred Crowley1 center occupancy [%]     baseline and  haloperidol       day:             • 0  ...... 3.30               • 30  ...... 6.62               • 60  ...... 2.50               • 120  ...... 5.56                 • time comparison   27 strains   age 9-28wks   Inbred Golani1 measure of center occupancy         • center occupancy  ...... -3.62         • proportion of incursions  ...... 0.455         • segment length  ...... 16.0         • intermediate incursions  ...... 19.3         • arena-crossings  ...... 3.67 ▼         8 strains   age 10wks   Inbred Golani1 spatial and temporal endpoints         • mid-incursions  ...... 12.8         • arena-crossings  ...... 8.90         • path-to-center  ...... 12.2         • center duration  ...... 0.565         5 strains   age 10wks   Inbred Schalkwyk1 center square occupancy [s]         • latency  ...... 171         • duration  ...... 4.98           • comparison   8 strains   age 9-11wks   Inbred Schalkwyk1 center square occupancy in the presence of a novel object         • latency  ...... 63.6 ▼         • duration  ...... 15.0 ▲         • frequency  ...... 8.00 ▲           • comparison   8 strains   age 9-11wks   Inbred Wahlsten1 average distance traveled in 1 min   [cm] ...... 341   360   21 strains   age 9wks   Inbred Spijker2 center occupancy         • duration  ...... 1.51         • entries  ...... 33.5           • comparison   12 strains   age 6wks   inbred and BXD   behavior — fear conditioning         fear conditioning chamber   HMDPpheno4 thigmotaxis [%]         all HMDP:             • pre-stimulus  ...... 54.5               • post-stimulus  ...... 55.8 ▼                 • comparison         inbreds:             • pre-stimulus  ...... 54.5               • post-stimulus  ...... 55.8                 • comparison         AXB BXA:             • pre-stimulus  ......             • post-stimulus  ......               • comparison         BXD:             • pre-stimulus  ...... 54.5               • post-stimulus  ...... 55.8 ▼                 • comparison         BXH:             • pre-stimulus  ......             • post-stimulus  ......               • comparison   94 strains   age 10wks   HMDP HMDPpheno4 velocity [cm/s]         all HMDP:             • pre-stimulus  ...... 5.94               • post-stimulus  ...... 3.93                 • comparison         inbreds:             • pre-stimulus  ...... 5.94               • post-stimulus  ...... 3.93                 • comparison         AXB BXA:             • pre-stimulus  ......             • post-stimulus  ......               • comparison         BXD:             • pre-stimulus  ...... 5.94               • post-stimulus  ...... 3.93                 • comparison         BXH:             • pre-stimulus  ......             • post-stimulus  ......               • comparison   94 strains   age 10wks   HMDP HMDPpheno4 immobility [%]         all HMDP:             • pre-stimulus  ...... 4.32 ▼               • post-stimulus  ...... 13.9 ▼                 • comparison         inbreds:             • pre-stimulus  ...... 4.32 ▼               • post-stimulus  ...... 13.9                 • comparison         AXB BXA:             • pre-stimulus  ......             • post-stimulus  ......               • comparison         BXD:             • pre-stimulus  ...... 4.32 ▼               • post-stimulus  ...... 13.9                 • comparison         BXH:             • pre-stimulus  ......             • post-stimulus  ......               • comparison   94 strains   age 10wks   HMDP HMDPpheno4 post-stimulus activity burst [cm/s]         • all  ...... 39.7         • inbreds  ...... 39.7         • AXB BXA  ......       • BXD  ...... 39.7         • BXH  ......       94 strains   age 10wks   HMDP   behavior — fear conditioning — contextual         fear conditioning chamber   Gould2 acute group, conditioning: immediate fear [%]     control and  nicotine       • control  ...... 41.0 ▲         nicotine dose (mg):             • 0.045  ...... 38.3 ▲               • 0.09  ...... 42.5 ▲               • 0.18  ...... 41.7 ▲                 • comparison   8 strains   age 8-12wks   Inbred Gould2 acute group, conditioning: contextual fear [%]     control and  nicotine       • control  ...... 25.6         nicotine dose (mg):             • 0.045  ...... 23.3               • 0.09  ...... 45.0               • 0.18  ...... 43.7                 • comparison   8 strains   age 8-12wks   Inbred Gould2 chronic group, conditioning: immediate fear [%]     control and  nicotine 12mg       • control  ...... 38.3 ▲         • nicotine  ...... 40.0 ▲           • comparison   8 strains   age 8-12wks   Inbred Gould2 chronic group, conditioning: contextual fear [%]     control and  nicotine 12mg       • control  ...... 23.3         • nicotine  ...... 25.0           • comparison   8 strains   age 8-12wks   Inbred Gould3 withdrawal group: conditioning: immediate fear [%]     control and  nicotine       • control  ...... 41.1 ▲         nicotine dose (mg)             • 3  ...... 42.9 ▲               • 6.3  ...... 37.5 ▲               • 12  ...... 42.8 ▲                 • comparison   8 strains   age 8-12wks   Inbred Gould3 withdrawal group: conditioning: contextual fear [%]     control and  nicotine       • control  ...... 28.3         nicotine dose (mg)             • 3  ...... 24.3               • 6.3  ...... 22.6               • 12  ...... 18.3                 • comparison   8 strains   age 8-12wks   Inbred HMDPpheno4 contextual thigmotaxis [%]         • all  ...... 61.9         • inbreds  ...... 61.9         • AXB BXA  ......       • BXD  ...... 61.9         • BXH  ......       94 strains   age 10wks   HMDP HMDPpheno4 contextual velocity [cm/s]         • all  ...... 5.63 ▲▲         • inbreds  ...... 5.63 ▲         • AXB BXA  ......       • BXD  ...... 5.63 ▲▲         • BXH  ......       94 strains   age 10wks   HMDP HMDPpheno4 contextual immobility [%]         • all  ...... 7.19 ▼         • inbreds  ...... 7.19 ▼         • AXB BXA  ......       • BXD  ...... 7.19 ▼         • BXH  ......       94 strains   age 10wks   HMDP   behavior — fear conditioning — cued         monitoring system   Gould2 acute group, cued fear: pre-cue [%]     control and  nicotine       • control  ...... 0.467         nicotine dose (mg):             • 0.045  ...... 0.560               • 0.09  ...... 1.11               • 0.18  ...... 1.68                 • comparison   8 strains   age 8-12wks   Inbred Gould2 acute group, cued fear: cue [%]     control and  nicotine       • control  ...... 50.5         nicotine dose (mg):             • 0.045  ...... 50.6               • 0.09  ...... 43.3               • 0.18  ...... 48.9                 • comparison   8 strains   age 8-12wks   Inbred Gould2 compare pre-cue vs. cue         control        nicotine dose (mg):             0.045              0.09              0.18              8 strains   age 8-12wks   Inbred Gould2 chronic group, cued fear: pre-cue [%]     control and  nicotine 12mg       • control  ...... 0.560         • nicotine  ...... 0           • comparison   8 strains   age 8-12wks   Inbred Gould2 chronic group, cued fear: cue [%]     control and  nicotine 12mg       • control  ...... 41.1 ▼         • nicotine  ...... 40.0 ▼           • comparison   8 strains   age 8-12wks   Inbred Gould2 compare pre-cue vs. cue         control        nicotine        8 strains   age 8-12wks   Inbred Gould3 withdrawal group: cued fear: pre-cue [%]     control and  nicotine       • control  ...... 1.60         nicotine dose (mg)             • 3  ...... 1.19               • 6.3  ...... 0.800               • 12  ...... 1.20                 • comparison   8 strains   age 8-12wks   Inbred Gould3 withdrawal group: cued fear: cue [%]     control and  nicotine       • control  ...... 56.0         nicotine dose (mg)             • 3  ...... 48.8               • 6.3  ...... 47.6               • 12  ...... 49.2                 • comparison   8 strains   age 8-12wks   Inbred HMDPpheno4 thigmotaxis [%]         all HMDP:             • pre-cue  ...... 81.0 ▲               • cue  ...... 69.3                 • comparison         inbreds:             • pre-cue  ...... 81.0 ▲               • cue  ...... 69.3                 • comparison         AXB BXA:             • pre-cue  ......             • cue  ......               • comparison         BXD:             • pre-cue  ...... 81.0 ▲               • cue  ...... 69.3                 • comparison         BXH:             • pre-cue  ......             • cue  ......               • comparison   94 strains   age 10wks   HMDP HMDPpheno4 velocity         all HMDP:             • pre-cue  ...... 3.51               • cue  ...... 0.838                 • comparison         inbreds:             • pre-cue  ...... 3.51               • cue  ...... 0.838                 • comparison         AXB BXA:             • pre-cue  ......             • cue  ......               • comparison         BXD:             • pre-cue  ...... 3.51               • cue  ...... 0.838                 • comparison         BXH:             • pre-cue  ......             • cue  ......               • comparison   94 strains   age 10wks   HMDP HMDPpheno4 immobility [%]         all HMDP:             • pre-cue  ...... 33.8 ▲               • cue  ...... 31.4                 • comparison         inbreds:             • pre-cue  ...... 33.8 ▲               • cue  ...... 31.4                 • comparison         AXB BXA:             • pre-cue  ......             • cue  ......               • comparison         BXD:             • pre-cue  ...... 33.8 ▲               • cue  ...... 31.4                 • comparison         BXH:             • pre-cue  ......             • cue  ......               • comparison   94 strains   age 10wks   HMDP   behavior — impulsivity         choice serial reaction time task   Spijker2 responses         • anticipatory  ...... 2.21         • latency to collect food  ...... 2.20         • impulsivity  ...... 20.1           • comparison   12 strains   age 6wks   inbred and BXD   behavior — impulsivity         Go/No-go task   Mitchell1 response         • pre-cue rate  ...... 0.0700         • Go hits  ...... 0.511         • No-go false alarms  ...... 0.382           • comparison   15 strains   age 5-7wks   Inbred Mitchell1 latency to respond [s]         • Go cue  ...... 2.38         • No-go cue  ...... 2.42           • comparison   15 strains   age 5-7wks   Inbred Mitchell1 measures of efficiency and discrimination [ratio]         • target specificity  ...... 0.905         • efficiency  ...... 0.232         • discrimination  ...... 0.355           • comparison   15 strains   age 5-7wks   Inbred   behavior — impulsivity         operant chamber   Jentsch1 acquisition performance [n]         • initiated trial  ...... 172 (N=4) ▲         • no choice made  ...... 18.2 (N=4)         • anticipatory  ...... 4.23 (N=4) ▲           • comparison   53 strains   age 17wks   BXD Jentsch1 acquisition latency [s]         • trial initiation  ...... 25.4 (N=4)         • correct choice  ...... 5.75 (N=4)         • reward retrieval  ...... 0.250 (N=4) ▼           • comparison   53 strains   age 17wks   BXD Jentsch1 reversal performance [n]         • initiated trial  ...... 234 (N=4) ▲         • no choice made  ...... 5.00 (N=4)         • anticipatory  ...... 2.20 (N=4)           • comparison   53 strains   age 17wks   BXD Jentsch1 reversal latency [s]         • trial initiation  ...... 16.5 (N=4)         • correct choice  ...... 4.82 (N=4)         • reward retrieval  ...... 0.250 (N=4)           • comparison   53 strains   age 17wks   BXD   behavior — involuntary movement         observation   Crowley1 tongue protrusion [n]     baseline and  haloperidol       day:             • 0  ...... 13.4               • 30  ...... 75.8 ▲▲               • 60  ...... 20.6               • 120  ...... 78.3 ▲▲                 • time comparison   27 strains   age 9-28wks   Inbred Crowley1 overt chewing movement [n]     baseline and  haloperidol       day:             • 0  ...... 5.11               • 30  ...... 63.2               • 60  ...... 68.8               • 120  ...... 47.6                 • time comparison   27 strains   age 9-28wks   Inbred Crowley1 subtle chewing movement [n]     baseline and  haloperidol       day:             • 0  ...... 25.1               • 30  ...... 112               • 60  ...... 89.6               • 120  ...... 96.0                 • time comparison   27 strains   age 9-28wks   Inbred Crowley1 jaw tremor [s]     baseline and  haloperidol       day:             • 0  ...... 9.56               • 30  ...... 35.8               • 60  ...... 25.6               • 120  ...... 18.6                 • time comparison   27 strains   age 9-28wks   Inbred   behavior — involuntary movement         open field test   Crowley1 repetitive behavior (stereotypy) [n]     baseline and  haloperidol       day:             • 0  ...... 4600               • 30  ...... 4785 ▲               • 60  ...... 4687               • 120  ...... 6839 ▲                 • time comparison   27 strains   age 9-28wks   Inbred   behavior — involuntary movement         SHIRPA   Jaxpheno7 constant trembling in view-jar (score 0-2)   [score] ...... 0   6 strains   age 10wks   Inbred Jaxpheno7 short sporadic twitches in view-jar (score 0-2)   [score] ...... 0   6 strains   age 10wks   Inbred   behavior — involuntary movement — handling-induced convulsion         observation   Metten2 peak handling-induced convulsion score [score]     control and  ethanol aerosolized       • control  ...... 1.47         • ethanol  ...... 4.25         • ethanol normalized to controls  ...... 2.78         15 strains   age 8-15wks   Inbred Metten2 latency to first score used to calculate peak ethanol   [h] ...... 3.75     ethanol   aerosolized 15 strains   age 8-15wks   Inbred Metten2 withdrawal severity during 0-25h (area under curve of HIC scores) [AUC]   ethanol   aerosolized       • ethanol  ...... 55.5         • ethanol normalized to controls  ...... 75.8 ▲▲         15 strains   age 8-15wks   Inbred   behavior — learning and memory         Morris water maze   Schalkwyk1 latency to reach visible platform   [s] ...... 23.9   8 strains   age 9-11wks   Inbred Schalkwyk1 latency to reach hidden platform [s]         trial:             • 1  ...... 10.5               • 2  ...... 17.7               • 3  ...... 12.7               • 4  ...... 16.5               • 5  ...... 9.58               • 6  ...... 11.1               • 7  ...... 9.07                 • trial comparison   8 strains   age 9-11wks   Inbred Schalkwyk1 latency to reach reversed platform [s]         • trial 1  ...... 14.9         • trial 2  ...... 15.8           • trial comparison   8 strains   age 9-11wks   Inbred   behavior — learning and memory         open field test   Golani1 locational memory and familiarity endpoints         • homebase preference  ...... -1.37         • homebase visits  ...... 4.07         • homebase lingering  ...... 12.8         8 strains   age 10wks   Inbred   behavior — learning and memory         puzzle box   Schalkwyk1 latency to reach goal [s]         • training period  ...... 20.8         • burrowing task  ...... 66.3         • plug task  ...... 76.2 ▼           • comparison   8 strains   age 9-11wks   Inbred   behavior — learning and memory — olfactory         olfactory discrimination task   Brown2 percent digging odor pot [%]         • lemon (CS+)  ...... 84.1   93.1         • rose (CS+)  ...... 71.3   73.7         • lemon (CS+) plus rose (CS+)  ...... 77.1   82.5         13 strains   age 10-18wks   Inbred Brown2 total time spent digging   [s] ...... 40.5   43.7   13 strains   age 10-18wks   Inbred   behavior — locomotor activity         elevated plus maze   Brown1 total activity (line crosses plus rearing, dur=5min))   [n] ...... 26.4   50.7   14 strains   age 10wks   Inbred Wahlsten1 distance traveled [cm]         during minute:             • 1  ...... 241   143               • 2  ...... 159   200               • 3  ...... 182   131               • 4  ...... 157   204               • 5  ...... 138   204                 • time comparison   21 strains   age 9wks   Inbred Wahlsten1 movement         • % time moving  ...... 21.1   22.1         • speed when moving  ...... 2.93   2.94         21 strains   age 9wks   Inbred Wiltshire1 total locomotor activity, 5 min   [cm] ...... 848 (N=4) ▼   903 (N=3) ▼   25 strains   age 12-14wks   Inbred Spijker2 activity [m]         • total distance  ...... 9.80         12 strains   age 6wks   inbred and BXD   behavior — locomotor activity         elevated zero maze   Brown1 total activity (line crosses plus rearing, dur=5min))   [n] ...... 43.7   50.2   13 strains   age 10wks   Inbred   behavior — locomotor activity         light-dark box   Brown1 total activity (line crosses plus rearing, dur=5min))   [n] ...... 125   148   14 strains   age 10wks   Inbred   behavior — locomotor activity         monitoring system   Crabbe2 horizontal distance traveled (immediately to 15 min post-injection) [cm]     baseline and  diazepam       • baseline  ...... 3368         doses mg/kg:             • 2  ...... 2902               • 4  ...... 2482               • 8  ...... 2339               • 16  ...... 1590                 • comparison   15 strains   age 6-7wks   Inbred Crabbe2 vertical (rearing) activity (immediately to 15 min post-injection) [n]     baseline and  diazepam       • baseline  ...... 210         doses mg/kg:             • 2  ...... 64.0               • 4  ...... 64.0               • 8  ...... 25.0               • 16  ...... 12.0                 • comparison   15 strains   age 6-7wks   Inbred Kas1 home cage activity [cm]         • novelty condition  ...... 7536         • day 3  ...... 46262           • comparison   6 strains   age 5-7mo   Inbred Mitchell1 ambulatory activity [cm]         • day2 activity  ...... 2689         • habituation  ...... -614         15 strains   age 5-7wks   Inbred Mogil2 amount of activity (number of beam breaks in 4h period) [n]         • light  ......       • dark  ...... 13088         • dark w/saline injection  ...... 10348           • time period comparison   12 strains   age 6-10wks   Inbred Richfield1 horizontal beam breaks         counts (45min session):             • daily avg  ...... 3924               • day1  ...... 3953               • day2  ...... 3987               • day3  ...... 3832                 • day1-3 comparison         • beam breaks per min  ...... 87.2         • short-term habituation  ...... -4.95         • long-term habituation  ...... -60.4         15 strains   age 7-9wks   Inbred Richfield1 ambulatory activity         counts (45min session):             • daily avg  ...... 2368               • day1  ...... 2458               • day2  ...... 2477               • day3  ...... 2169                 • day1-3 comparison         • ambulatory activity per min  ...... 52.6         • short-term habituation  ...... -4.00         • long-term habituation  ...... -145         15 strains   age 7-9wks   Inbred Richfield1 vertical beam breaks (rearing)         counts (45min session):             • daily avg  ...... 273               • day1  ...... 234               • day2  ...... 355               • day3  ...... 229                 • day1-3 comparison         • beam breaks per min  ...... 6.04         • short-term habituation  ...... -0.212         • long-term habituation  ...... -2.50         15 strains   age 7-9wks   Inbred Richfield1 compare habituation for the above tests         short-term habituation        long-term habituation        15 strains   age 7-9wks   Inbred Thomsen1 total activity, test 1 [n]     baseline and  cocaine       • baseline  ...... 775   669         dose mg/kg i.p.:             • 3  ...... 834   1030               • 10  ...... 948   1181               • 18  ...... 1766   1535               • 32  ...... 2738   3611               • 56  ...... 3877   5165                 • comparison   15 strains   age 8-10wks   Inbred Thomsen1 total activity, test 2 [n]     baseline and  cocaine       • baseline  ...... 950   1055         dose mg/kg i.p.:             • 3  ...... 2600   1115               • 10  ...... 5724   2766               • 32  ...... 6978   6892                 • comparison   15 strains   age 8-10wks   Inbred Thomsen1 comparison of test1 vs. test2   cocaine         baseline        dose mg/kg i.p.:             3              10              32              15 strains   age 8-10wks   Inbred Thomsen2 total activity, dose response to D1 agonist [n]     baseline and  R-6-Br-APB       • baseline  ...... 763   1283         dose mg/kg i.p.             • 0.03  ...... 1058   1414               • 0.32  ...... 2000   2819               • 3.2  ...... 3625   4713 (N=1)               • 5.6  ......               • comparison   15 strains   age 8-10wks   Inbred Thomsen2 total activity, dose response to D2 agonist [n]     baseline and  quinelorane       • baseline  ...... 1426   839         dose mg/kg i.p.             • 0.03  ...... 745   376               • 0.32  ...... 162   114               • 3.2  ...... 498   336               • 5.6  ...... 179   384                 • comparison   15 strains   age 8-10wks   Inbred Thomsen2 comparison of D1 agonist vs. D2 agonist         baseline        dose mg/kg i.p.             0.03              0.32              3.2              5.6              15 strains   age 8-10wks   Inbred   behavior — locomotor activity         open field test   Brown1 total locomotor activity (line crosses plus rearing, dur=5min), day 1   [n] ...... 132   165   14 strains   age 10wks   Inbred Crowley1 distance traveled [cm]     baseline and  haloperidol       day:             • 0  ...... 6686               • 30  ...... 4912               • 60  ...... 4251               • 120  ...... 6421                 • time comparison   27 strains   age 9-28wks   Inbred Crowley1 vertical activity [n]     baseline and  haloperidol       day:             • 0  ...... 664               • 30  ...... 375               • 60  ...... 360               • 120  ...... 581                 • time comparison   27 strains   age 9-28wks   Inbred Golani1 locomotor activity         • distance traveled  ...... 15996         • latency to maximum velocity  ...... 4.78 ▲         • change in activity at half-time  ...... -0.152         8 strains   age 10wks   Inbred Golani1 high-speed motion (progression segment) endpoints         • darting episodes  ...... 283         • distance  ...... 5.52         • maximal speed  ...... 35.2         • acceleration  ...... 3.37 ▲         • turn radius  ...... 1.23 ▲         • turn rate  ...... 32.1         8 strains   age 10wks   Inbred Golani1 low-speed motion (lingering segment) endpoints         • lingering mean  ...... 1.91         • duration  ...... 0.756         • special spread  ...... 0.954         • diversity of motion  ...... 1.87         8 strains   age 10wks   Inbred Metten1 line crossings, 2.75 g/kg injection [n]     control and  ethanol 2.75g/kg i.p.       • pre-injection  ...... 5.14   2.00 (N=4) ▼         • 10min after injection  ...... 8.86   15.0 (N=3)         • 30min after  ...... 8.00   12.0 (N=3)           • comparison   9 strains   age 8-11wks   Inbred Metten1 line crossings, 3.0 g/kg injection [n]     control and  ethanol 3.0g/kg i.p.       • pre-injection  ...... 5.75   2.25 (N=4) ▼         • 10min after injection  ...... 2.38   7.25 (N=4)         • 30min after  ...... 15.2   15.3 (N=3)           • comparison   9 strains   age 8-11wks   Inbred Metten1 line crossings, compare dose groups     control and  ethanol       pre-injection        10min after injection        30min after        9 strains   age 8-11wks   Inbred Pletcher1 total distance traveled, 7 min   [cm] ...... 1065   31 strains   age 7-10wks*   Inbred Schalkwyk1 total activity         • center  ...... 18.8         • periphery  ...... 66.2         • rearing in presence of novel object  ...... 13.0           • comparison   8 strains   age 9-11wks   Inbred Wahlsten1 distance traveled [cm]         during minute:             • 1  ...... 347 ▼   418               • 2  ...... 331 ▼   368               • 3  ...... 364   362               • 4  ...... 370   330               • 5  ...... 294   320                 • time comparison   21 strains   age 9wks   Inbred Wahlsten1 average speed over 5 min trial   [cm/sec] ...... 5.69   6.00   21 strains   age 9wks   Inbred Wiltshire1 total activity [cm]         • activity  ...... 2064   2054         • rearing  ...... 78.0   79.5         37 strains   age 12-14wks   Inbred Wiltshire2 OFT distance traveled [cm]     control and  fluoxetine       • control  ...... 1085         • fluoxetine  ...... 1824           • comparison   30 strains   age 10-11wks   Inbred Spijker2 activity         • total distance  ...... 86.8         • stops  ...... 0.0400         • acceleration  ...... 26.2         • distance per progression  ...... 16.8         • number of progressions  ...... 35.4         • duration of progression  ...... 0.850         • lingering episode  ...... 144           • comparison   12 strains   age 6wks   inbred and BXD   behavior — locomotor activity         parallel rod floor test   Crabbe5 distance traveled, 1.6mm rod, 6mm space [cm]     control and  ethanol       • day1 control  ...... 790   783 (N=4)         • day2 control  ...... 821 ▲   1036 (N=4)         • day3 ethanol  ...... 1761 ▲   1894 (N=4) ▲           • comparison   8 strains   age 8-10wks   Inbred   behavior — locomotor activity         SHIRPA   Jaxpheno7 spontaneous activity level in view-jar (score 0-3)   [score] ...... 1.36   6 strains   age 10wks   Inbred   behavior — social — preference for social novelty test         operant chamber   Moy1 duration of time spent [s]         • with former novel mouse  ...... 213         • with second novel mouse  ...... 200 ▼         • in homebase  ...... 187           • comparison   17 strains   age 6-7wks   Inbred Moy1 exploratory sniffing in cage with: [s]         • former novel mouse  ...... 31.4         • second novel mouse  ...... 36.0 ▼           • comparison   17 strains   age 6-7wks   Inbred Moy1 repeat entry to chamber: [n]         • with former novel mouse  ...... 9.71         • with second novel mouse  ...... 9.13           • comparison   17 strains   age 6-7wks   Inbred   behavior — social — sociability test         operant chamber   Moy1 duration of time spent [s]         • with novel mouse  ...... 210         • with novel object  ...... 241         • in homebase  ...... 149           • comparison   17 strains   age 6-7wks   Inbred Moy1 exploratory sniffing in cage with: [s]         • novel mouse  ...... 51.1 ▼         • novel object  ...... 16.7           • comparison   17 strains   age 6-7wks   Inbred Moy1 repeat entry to chamber: [n]         • with novel mouse  ...... 7.82         • with novel object  ...... 7.76           • comparison   17 strains   age 6-7wks   Inbred   behavior — stress reactivity         forced swim test   Gould1 duration of immobility [s]     control and  lithium       lithium dose [mg/kg]:             • 0(saline)  ...... 141               • 200  ...... 132               • 300  ...... 119               • 400  ...... 103                 • comparison   11 strains   age 7-8wks   Inbred   behavior — stress reactivity         light-dark box   Gershenfeld1 number of transitions between light and dark compartments in 10 min [n]     baseline and  imipramine       • baseline  ...... 12.0 (N=2)         • imipramine 30mg/kg  ...... 16.6           • comparison   12 strains   age 5-10wks   Inbred   behavior — stress reactivity         open field test   Gershenfeld1 distance traveled in 5 min [cm]     baseline and  imipramine       • baseline  ...... 820         • imipramine 30mg/kg  ...... 902           • comparison   12 strains   age 5-10wks   Inbred Gershenfeld1 vertical movements (rearing) in 15 min [n]     baseline and  imipramine       • baseline  ...... 83.6         • imipramine 30mg/kg  ...... 92.6           • comparison   12 strains   age 5-10wks   Inbred Gershenfeld1 average center time, 2 trials [s]     baseline and  imipramine       • baseline  ...... 42.0 ▼         • imipramine 30mg/kg  ...... 78.8           • comparison   12 strains   age 5-10wks   Inbred Gershenfeld1 number of fecal boli in 15 min [n]     baseline and  imipramine       • baseline  ...... 3.60         • imipramine 30mg/kg  ...... 4.80           • comparison   12 strains   age 5-10wks   Inbred   behavior — stress reactivity         tail suspension test   Gershenfeld1 TST duration of immobility, effect of saline injection on control group [s]         • before injection  ...... 202 ▼         • after injection  ...... 266           • comparison   12 strains   age 5-10wks   Inbred Gershenfeld1 TST duration of immobility, treatment group [s]     baseline and  imipramine       • baseline  ...... 227         • imipramine 30mg/kg  ...... 180 ▼           • comparison   12 strains   age 5-10wks   Inbred Gershenfeld1 TST immobility percentage, imipramine vs. saline   [%] ...... -32.3 ▼     imipramine   12 strains   age 5-10wks   Inbred Pletcher1 TST immobility percentage   [%] ...... 17.2 ▼   30 strains   age 7-10wks*   Inbred Schalkwyk1 TST duration of immobility [s]         • trial 1  ...... 76.3 ▼▼         • trial 2  ...... 122 ▼           • trial comparison   8 strains   age 9-11wks   Inbred Wiltshire2 TST duration of immobility [%]     control and  fluoxetine       • control  ...... 12.3 ▼         • fluoxetine  ...... 5.29 ▼           • comparison   30 strains   age 9-10wks   Inbred   behavior — visuospatial learning         Barnes circular maze   Brown2 acquisition training mean errors [n]         • day1  ...... 20.8   13.9         • day4  ...... 10.2   7.04         13 strains   age 10-18wks   Inbred Brown2 reversal training mean errors [n]         • day1  ...... 9.45   10.1         • day4  ...... 6.25   4.14         13 strains   age 10-18wks   Inbred Brown2 acquisition training mean latency to escape [s]         • day1  ...... 192   137         • day4  ...... 138   51.9         13 strains   age 10-18wks   Inbred Brown2 reversal training mean latency to escape [s]         • day1  ...... 121   66.0         • day4  ...... 100   42.0         13 strains   age 10-18wks   Inbred Brown2 probe trial correct quadrant         • entries  ...... 7.33   11.0         • duration  ...... 90.6   88.3         • % correct  ...... 30.3   29.6         13 strains   age 10-18wks   Inbred   behavior — visuospatial learning         Morris water maze   Brown2 mean distance traveled to find hidden platform, day 3 [cm]         • acquisition training  ...... 676   489 ▼         • reversal training  ...... 728   267           • comparison   14 strains   age 10-18wks   Inbred Brown2 mean velocity, day 3 [cm/s]         • acquisition training  ...... 29.4 ▲   22.8         • reversal training  ...... 26.0   26.0           • comparison   14 strains   age 10-18wks   Inbred Brown2 mean latency to find hidden platform, day 3 [s]         • acquisition training  ...... 22.7 ▼   22.3 ▼         • reversal training  ...... 28.0   11.1 ▼           • comparison   14 strains   age 10-18wks   Inbred Brown2 probe trial, correct quadrant         • duration  ...... 22.2   27.6 ▲         • % time  ...... 37.1   46.0 ▲         14 strains   age 10-18wks   Inbred Brown2 mean time within pool edge, across all aquistion and reversal trials   [s] ...... 11.6   7.49 ▼   14 strains   age 10-18wks   Inbred Brown2 mean latency to find visible platform   [s] ...... 69.2   47.3 ▼   14 strains   age 10-18wks   Inbred   behavior — visuospatial learning — visual acuity         visual water box   Brown2 percent correct [%]         grating threshold:             • 0.17 (low)  ...... 83.8   97.6 ▲▲               • 0.32  ...... 67.5   84.2 ▲               • 0.64 (high)  ...... 36.2   35.4               14 strains   age 10-18wks   Inbred Brown2 latency to reach cued platform [s]         grating threshold:             • 0.17 (low)  ...... 4.93   7.45               • 0.32  ...... 6.99   10.9               • 0.64 (high)  ...... 12.2   21.3               • overall mean  ...... 5.30 ▼   15.1               14 strains   age 10-18wks   Inbred   behavior — visuospatial learning — visual discrimination         visual water box   Brown2 percent correct, 0.17 grating threshold (low), day 8 [%]         • visual detection  ...... 93.8 ▲   95.8 ▲         • pattern discrimination  ...... 86.2 ▲   95.8 ▲▲         14 strains   age 10-18wks   Inbred Brown2 mean latency to reach cued platform, 0.17 grating threshold (low), day 8 [s]         • visual detection  ...... 4.64 ▼   5.52 ▼         • pattern discrimination  ...... 5.52 ▼   9.44 ▼         14 strains   age 10-18wks   Inbred   behavior — wildness         observation   Wahlsten2 number of tests with: [score]         • sqeaks  ...... 4.90 ▲   4.12         • bites  ...... 0.100   0.125         • escapes  ...... 0.100   0         • no wildness events  ...... 8.00   9.50         21 strains   age 10-12wks   Inbred Wahlsten2 overall mean ratings [score]         • capture rating  ...... 0.425   0.124         • hold rating  ...... 0.350   0.375         21 strains   age 10-12wks   Inbred Wahlsten2 wildness rating during: [score]         • capture and hold  ...... 0.775   0.534         • OF and EPM  ...... 0.150   0.125         • rotarod  ...... 0.950   0.650         • water escape  ...... 0.980   0.771         • weighing  ...... 0.417   0.125         21 strains   age 10-12wks   Inbred   behavior — wildness         SHIRPA   Jaxpheno7 aggressive behavior [score]         • provoked biting  ...... 1.00         • irritability  ...... 0.636         • aggression  ...... 1.00         • vocalization  ...... 0.636 ▲         • finger approach  ...... 0.545         6 strains   age 10wks   Inbred 664 measurements listed.

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