behavior — anxiety         elevated plus maze   Brown1 open arms avoidance index   [n] ...... 0.741   0.704   14 strains   age 10wks   Inbred Brown1 durations of anxiety related behaviors [s]         • closed arms  ...... 172   137 ▲         • grooming  ...... 30.6 ▲▲   9.29 ▲         14 strains   age 10wks   Inbred Brown1 counts of anxiety related behaviors [n]         • closed arms entries  ...... 8.42   11.4         • fecal boli  ...... 3.85 ▲   2.77         • head-dips  ...... 8.62   10.2 ▼         • stretch attends  ...... 5.31   4.00         • urine puddles  ...... 1.54   1.62         14 strains   age 10wks   Inbred Brown1 closed arms, proportion of total time   [ratio] ...... 0.576   0.460 ▲   14 strains   age 10wks   Inbred Gould2 chronic group: time in closed arms [%]     control and  nicotine 12mg       • control  ...... 65.2 ▲         • nicotine  ...... 62.5 ▲           • comparison   8 strains   age 8-12wks   Inbred Gould2 chronic group: time in open arms [%]     control and  nicotine 12mg       • control  ...... 14.6 ▼         • nicotine  ...... 18.2 ▼           • comparison   8 strains   age 8-12wks   Inbred Gould2 chronic group: time in center [%]     control and  nicotine 12mg       • control  ...... 20.8         • nicotine  ...... 18.7           • comparison   8 strains   age 8-12wks   Inbred Gould3 withdrawal group: time in closed arms [%]     control and  nicotine       • control  ...... 57.3 ▲         nicotine dose (mg)             • 3  ...... 65.8 ▲               • 6.3  ...... 55.1 ▲               • 12  ...... 71.6 ▲                 • comparison   8 strains   age 8-12wks   Inbred Gould3 withdrawal group: time in open arms [%]     control and  nicotine       • control  ...... 21.3 ▼         nicotine dose (mg)             • 3  ...... 17.5 ▼               • 6.3  ...... 15.2 ▼               • 12  ...... 15.4 ▼                 • comparison   8 strains   age 8-12wks   Inbred Gould3 withdrawal group: time in center [%]     control and  nicotine       • control  ...... 21.6         nicotine dose (mg)             • 3  ...... 16.9               • 6.3  ...... 30.0               • 12  ...... 13.3                 • comparison   8 strains   age 8-12wks   Inbred Schalkwyk1 closed arms occupancy         • number of entries  ...... 10.8         • duration  ...... 188 ▲           • comparison   8 strains   age 9-11wks   Inbred Wahlsten1 time spent in two closed arms   [s] ...... 42.3 ▲   40.2 ▲   21 strains   age 9wks   Inbred Wahlsten1 number fecal boli, 5 min trial   [n] ...... 2.50   2.00   21 strains   age 9wks   Inbred Wahlsten1 percent time spent in open arms vs closed   [%] ...... 15.9 ▼   17.8 ▼   21 strains   age 9wks   Inbred Spijker2 closed arms occupancy [n]         • entries  ...... 19.9         12 strains   age 6wks   inbred and BXD   behavior — anxiety         elevated zero maze   Brown1 durations of anxiety related behaviors [s]         • in closed zone  ...... 251 ▲   206         • grooming  ...... 0.393   0.247         13 strains   age 10wks   Inbred Brown1 counts of anxiety related behaviors [n]         • closed zone entries  ...... 7.17   11.5         • fecal boli  ...... 1.00   1.80         • head-dips  ...... 6.50 ▼   11.4         • stretch attends  ...... 13.8   8.70         • urine puddles  ...... 0.667   1.30         13 strains   age 10wks   Inbred Brown1 closed zone, proportion of total time   [ratio] ...... 0.840 ▲   0.689   13 strains   age 10wks   Inbred Flaherty1 latency to enter open quadrant   [s] ...... 107   90.5 ▲   8 strains   age 8-9wks   Inbred Flaherty1 duration in open quadrants [s]         • total  ...... 24.6   30.1         • q2  ...... 9.82 ▼   15.7         • q4  ...... 14.8   14.4         8 strains   age 8-9wks   Inbred Flaherty1 duration in closed quadrants [s]         • total  ...... 275   270         • q1  ...... 229   225         • q3  ...... 46.7   44.6         8 strains   age 8-9wks   Inbred Flaherty1 number beam breaks in closed quadrants   [n/s] ...... 306 ▼   389   8 strains   age 8-9wks   Inbred Flaherty1 percent of time in open quadrants [%]         • both  ...... 8.21   10.0         • q2  ...... 3.27 ▼   5.23         • q4  ...... 4.94   4.80         8 strains   age 8-9wks   Inbred Flaherty1 percent of time in closed quadrants [%]         • q1  ...... 76.2   75.1         • q3  ...... 15.6   14.9         8 strains   age 8-9wks   Inbred Flaherty1 total number fecal boli   [n] ...... 4.55   3.50   8 strains   age 8-9wks   Inbred   behavior — anxiety         light-dark box   Brown1 durations of anxiety related behaviors [s]         • in dark zone  ...... 244   212         • grooming  ...... 12.9 ▲   5.73         14 strains   age 10wks   Inbred Brown1 counts of anxiety related behaviors [n]         • fecal boli  ...... 3.57   3.31         • stretch attends  ...... 5.50   3.31         • urine puddles  ...... 1.07   1.08         14 strains   age 10wks   Inbred   behavior — anxiety         observation   Gould2 chronic group: grooming [n]     control and  nicotine 12mg       • control  ...... 3.70         • nicotine  ...... 4.10           • comparison   8 strains   age 8-12wks   Inbred Gould2 chronic group: scratching [n]     control and  nicotine 12mg       • control  ...... 0.700         • nicotine  ...... 0.500           • comparison   8 strains   age 8-12wks   Inbred Gould2 chronic group: jumping [n]     control and  nicotine 12mg       • control  ...... 0.100         • nicotine  ...... 0           • comparison   8 strains   age 8-12wks   Inbred Gould3 withdrawal group: grooming [n]     control and  nicotine       • control  ...... 6.25 ▲         nicotine dose (mg)             • 3  ...... 4.60 ▲▲               • 6.3  ...... 5.70 ▲               • 12  ...... 6.00 ▲                 • comparison   8 strains   age 8-12wks   Inbred Gould3 withdrawal group: scratching [n]     control and  nicotine       • control  ...... 3.00 ▲         nicotine dose (mg)             • 3  ...... 0.900               • 6.3  ...... 3.80 ▲               • 12  ...... 2.50 ▲                 • comparison   8 strains   age 8-12wks   Inbred Gould3 withdrawal group: jumping [n]     control and  nicotine       • control  ...... 0.167         nicotine dose (mg)             • 3  ...... 0.100               • 6.3  ...... 0.200               • 12  ...... 0                 • comparison   8 strains   age 8-12wks   Inbred   behavior — anxiety         open field test   Brown1 counts of anxiety related behaviors [n]         • fecal boli  ...... 1.93   1.77         • stretch attends  ...... 3.93   1.77         • urine puddles  ...... 1.29   1.15         14 strains   age 10wks   Inbred Brown1 durations of anxiety related behaviors [s]         • freezing  ...... 0.388   0.495         • grooming  ...... 12.7 ▲   6.21         14 strains   age 10wks   Inbred Golani1 thigmotaxis endpoints         • near-wall  ...... 39.5 ▼         • curvature  ...... 4.03 ▼         • duration  ...... 1.42         • incursions  ...... 14.0         5 strains   age 10wks   Inbred Golani1 measure of center avoidance         • median length  ...... 20.3         • incursions  ...... 62.4 ▼         • median incursions  ...... 5.06 ▼         • outbound/inbound speeds  ...... 0.839 ▼         5 strains   age 10wks   Inbred Pletcher1 percent of center avoidance (thigmotaxis)   [%] ...... 96.0 ▲   31 strains   age 7-10wks*   Inbred Wahlsten1 percent of 5 min spent within 10 cm of wall   [%] ...... 83.8   83.7   21 strains   age 9wks   Inbred Wahlsten1 number of fecal boli, within 5 min trial   [n] ...... 0.800 ▼   1.88   21 strains   age 9wks   Inbred Wiltshire2 OFT center avoidance (thigmotaxis) [%]     control and  fluoxetine       • control  ...... 94.4 ▲         • fluoxetine  ...... 97.4 ▲           • comparison   30 strains   age 10-11wks   Inbred   behavior — anxiety         SHIRPA   Jaxpheno7 degree of behavioral inhibition or arousal [score]         • transfer arousal  ...... 1.27         • freezing  ...... 0.545         6 strains   age 10wks   Inbred Jaxpheno7 frequency of behavioral displacement (jar) [n]         • defecation  ...... 0.0909         • urination  ...... 0         6 strains   age 10wks   Inbred Jaxpheno7 frequency of behavioral displacement (arena) [n]         • defecation  ...... 1.45         • urination  ...... 0         6 strains   age 10wks   Inbred

102 measurements listed.