|
kidney — function — flow
gauge
|
|
|
|
Inbred
|
|
|
|
Inbred
|
| |
|
kidney — function — urinalysis
ELISA
|
|
|
urine kidney injury molecule 1 (KIM-1)
[pg]
control and
DB289
......
3756
(N=4)
......
115
......
0.0310
|
Inbred
|
| |
|
kidney — function — urinalysis
spectrophotometry
|
|
|
urine alcohol concentration (UAC), daily average
[mg/dL]
high-fat diet
, ethanol
......
14.3
(N=3)
......
200
(N=3)
|
Inbred
|
|
|
urine alcohol concentration (UAC), daily peak
[mg/dL]
high-fat diet
, ethanol
......
35.7
(N=3)
......
556
(N=3)
|
Inbred
|
| |
|
kidney — function — urinalysis
urinalysis
|
|
|
|
Inbred
|
|
|
|
Inbred
|
|
|
|
Inbred
|
|
|
urine volume
[mL]
control and
DB289
......
1.10
......
0.880
......
0.800
|
Inbred
|
|
|
creatinine (urine CREA)
[mg/mL]
control and
DB289
......
0.217
(N=4)
......
0.192
......
0.885
|
Inbred
|
| |
|
kidney — morphology — area
metric
|
|
|
kidney planar surface area
[mm2]
......
5.03
(N=4)
5.76
......
4.48
(N=4)
5.17
|
Inbred
|
|
|
normalized kidney planar surface area
[mm2/g]
......
3.77
(N=4)
3.97
......
3.35
(N=4)
3.57
|
Inbred
|
| |
|
kidney — morphology — weight
scales
|
|
|
kidney weight
[mg]
weight:
......
309
399
......
150
193
......
159
206
normalized:
......
11.7
14.5
......
5.73
7.01
......
6.01
7.48
|
Inbred
|
|
|
kidney weight
[g]
......
0.00690
(N=4)
0.00730
......
0.00705
(N=4)
0.00785
......
0.0140
(N=4)
0.0151
|
Inbred
|
|
|
percent kidney weight to body weight
[%]
......
0.514
(N=4)
0.502
......
0.523
(N=4)
0.540
......
1.04
(N=4)
1.04
|
Inbred
|
|
|
kidney (left) weight
[g]
control and
DB289
......
0.138
......
0.114
|
Inbred
|
|
|
kidney (right) weight
[g]
control and
DB289
......
0.148
......
0.120
|
Inbred
|
|
|
kidney (both) weight
[g]
control and
DB289
......
0.288
......
0.234
|
Inbred
|
|
|
total kidney weight as percent of body weight
[%]
control and
DB289
......
1.38
......
1.48
......
1.07
|
Inbred
|
|
|
kidney weight
......
0.562
......
1.63
|
Inbred
|
| |
|
kidney — xenobiotics — drug and metabolite concentration
HPLC
|
|
|
kidney metabolite (DB75) concentration
[µM]
control and
DB289
......
0.500
(N=2)
......
1043
|
Inbred
|