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Phenotype data: blood--xenobiotics -- drug and metabolite concentration blood – xenobiotics
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alcohol concentration (12)
drug and metabolite concentration (65)
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Focus:drug and metabolite concentration
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blood — xenobiotics — drug and metabolite concentration         flame photometry  
Gould1
serum lithium concentration [mmol/L]   lithium      
lithium dose [mg/kg]: • 200  • 300  • 400      comparison  
11 strains   age 7-8wks
  Inbred
 
blood — xenobiotics — drug and metabolite concentration         HPLC  
Rusyn2
dichloroacetic acid (serum DCA x 10-3) [nmol/mL]   trichloroethylene      
treated group:  • 2h  • 8h  • 24h      time comparison  
17 strains   age 7wks
  Inbred
Rusyn2
trichloroacetic acid (serum TCA) [nmol/mL]   trichloroethylene      
treated group:  • 2h  • 8h  • 24h      time comparison  
17 strains   age 7wks
  Inbred
Rusyn2
DCV cysteine (serum DCVC x 10-3) [nmol/mL]   trichloroethylene      
treated group:  • 2h  • 8h  • 24h      time comparison  
17 strains   age 7wks
  Inbred
Rusyn2
DCV glutathione (serum DCVG x 10-3) [nmol/mL]   trichloroethylene      
treated group:  • 2h  • 8h  • 24h      time comparison  
17 strains   age 7wks
  Inbred
Rusyn2
above metabolites compared   trichloroethylene      
treated group:  2h  8h  24h 
17 strains   age 7wks
  Inbred
Threadgill2
serum acetominophen (APAP) [µg/mL]     baseline and  acetaminophen 50mg/kg      
• baseline  • 0.5h  • 1h  • 2h  • 3h  • 6h      time comparison  
5 strains   age 6-8wks
  Inbred
Threadgill2
serum acetaminophen sulfate (APAP-sulfate) [µg/mL]     baseline and  acetaminophen 50mg/kg      
• baseline  • 0.5h  • 1h  • 2h  • 3h  • 6h      time comparison  
5 strains   age 6-8wks
  Inbred
Threadgill2
serum acetaminophen glucuronide (APAP-Glc) [µg/mL]     baseline and  acetaminophen 50mg/kg      
• baseline  • 0.5h  • 1h  • 2h  • 3h  • 6h      time comparison  
5 strains   age 6-8wks
  Inbred
Threadgill2
serum acetominophen (APAP) [µg/mL]     baseline and  acetaminophen 300mg/kg      
• baseline  • 0.5h  • 1h  • 2h  • 3h  • 6h      time comparison  
5 strains   age 6-8wks
  Inbred
Threadgill2
serum acetaminophen sulfate (APAP-sulfate) [µg/mL]     baseline and  acetaminophen 300mg/kg      
• baseline  • 0.5h  • 1h  • 2h  • 3h  • 6h      time comparison  
5 strains   age 6-8wks
  Inbred
Threadgill2
serum acetaminophen glucuronide (APAP-Glc) [µg/mL]     baseline and  acetaminophen 300mg/kg      
• baseline  • 0.5h  • 1h  • 2h  • 3h  • 6h      time comparison  
5 strains   age 6-8wks
  Inbred
Wiltshire2
drug and metabolite concentration [ng/mL]   fluoxetine      
• fluoxetine  • norfluoxetine      comparison  
30 strains   age 10-11wks
  Inbred
 
blood — xenobiotics — drug and metabolite concentration         HPLC/MS  
Rusyn6
trichloroacetic acid (serum TCA)   [nmol/mL]   trichloroethylene 7 strains   age 6-7wks
  Inbred
Rusyn6
dichloroacetic acid (serum DCA)   [nmol/mL]   trichloroethylene 7 strains   age 6-7wks
  Inbred
Rusyn6
S-(1,2-dichlorovinyl) glutathione (serum DCVG)   [pmol/mL]   trichloroethylene 7 strains   age 6-7wks
  Inbred
Rusyn6
S-(1,2-dichlorovinyl)-L-cysteine (serum DCVC)   [pmol/mL]   trichloroethylene 7 strains   age 6-7wks
  Inbred
 
blood — xenobiotics — drug and metabolite concentration         mass spectrometry  
Crowley1
plasma haloperidol concentration [nM]   haloperidol      
day: • 30  • 60  • 90  • 120      time comparison  
27 strains   age 9-28wks
  Inbred
Gould2
plasma nicotine [ng/mL]   nicotine      
• acute 0.09mg dose  • chronic 6.3mg dose      comparison  
8 strains   age 8-12wks
  Inbred
Gould2
plasma cotinine [ng/mL]   nicotine      
• acute 0.09mg dose  • chronic 6.3mg dose      comparison  
8 strains   age 8-12wks
  Inbred
Gould2
compare nicotine vs. cotinine        
acute 0.09mg dose  chronic 6.3mg dose 
8 strains   age 8-12wks
  Inbred


 


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