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MRL/MpJ strain
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blood – xenobiotics
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drug and metabolite concentration
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Phenotype data: blood--xenobiotics all
Measurements:
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MRL/MpJ
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blood — xenobiotics — drug and metabolite concentration
HPLC
Wiltshire2
drug and metabolite concentration [ng/mL]
fluoxetine
• fluoxetine
......
1067
• norfluoxetine
......
1047
• comparison
30
strains
age
10-11wks
Inbred
blood — xenobiotics — drug and metabolite concentration
mass spectrometry
Crowley1
plasma haloperidol concentration [nM]
haloperidol
day:
• 30
......
22.2
• 60
......
17.8
• 90
......
5.38
▼
• 120
......
3.82
• time comparison
27
strains
age
9-28wks
Inbred
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