Home       About             Help       Phenotype data > AKR/J strain > blood – xenobiotics Options: alcohol concentration drug and metabolite concentration all Focus: all Measurements: About these AKR/J averages (♀ ♂) Exit AKR/J mode blood — xenobiotics — alcohol concentration         gas chromatography   Crabbe4 blood ethanol concentration (BEC), 35 min post-injection, dowel (15.8 mm) test   [mg/mL] ......   ethanol 2g/kg i.p. 8 strains   age 12-16wks   Inbred Crabbe4 blood ethanol levels following grip strength test at various times after treatment [mg/mL]   ethanol 2g/kg i.p.       time after ethanol:             • 30min  ...... 1.11 ▼   1.36 ▼               • 60min  ...... 1.30 ▼   1.78               • 105min  ...... 0.808 ▼   1.35               • 150min  ...... 0.200 ▼   0.848                 • time comparison   21 strains   age 7-12wks   Inbred   blood — xenobiotics — alcohol concentration         spectrophotometry   Rusyn5 blood alcohol concentration (BAC) [mg/dL]   high-fat diet , ethanol       • high-fat only  ...... 28.2 (N=3)         • high-fat and ethanol  ...... 32.5 (N=3) ▼           • comparison   14 strains   age 8-14wks   Inbred   blood — xenobiotics — drug and metabolite concentration         HPLC   Rusyn2 dichloroacetic acid (serum DCA x 10-3) [nmol/mL]   trichloroethylene       treated group:             • 2h  ......             • 8h  ......             • 24h  ......               • time comparison   17 strains   age 7wks   Inbred Rusyn2 trichloroacetic acid (serum TCA) [nmol/mL]   trichloroethylene       treated group:             • 2h  ......             • 8h  ......             • 24h  ......               • time comparison   17 strains   age 7wks   Inbred Rusyn2 DCV cysteine (serum DCVC x 10-3) [nmol/mL]   trichloroethylene       treated group:             • 2h  ......             • 8h  ......             • 24h  ......               • time comparison   17 strains   age 7wks   Inbred Rusyn2 DCV glutathione (serum DCVG x 10-3) [nmol/mL]   trichloroethylene       treated group:             • 2h  ......             • 8h  ...... 0.313 (N=2)               • 24h  ......               • time comparison   17 strains   age 7wks   Inbred Rusyn2 above metabolites compared   trichloroethylene       treated group:             2h              8h              24h              17 strains   age 7wks   Inbred Wiltshire2 drug and metabolite concentration [ng/mL]   fluoxetine       • fluoxetine  ...... 988         • norfluoxetine  ...... 1119           • comparison   30 strains   age 10-11wks   Inbred   blood — xenobiotics — drug and metabolite concentration         mass spectrometry   Crowley1 plasma haloperidol concentration [nM]   haloperidol       day:             • 30  ...... 12.7 ▼               • 60  ...... 11.0 ▼               • 90  ...... 4.62 ▼               • 120  ...... 2.66 ▼                 • time comparison   27 strains   age 9-28wks   Inbred

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