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blood – xenobiotics
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alcohol concentration
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Phenotype data: blood--xenobiotics all
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blood — xenobiotics — alcohol concentration
gas chromatography
Crabbe4
blood ethanol concentration (BEC), 35 min post-injection, dowel (15.8 mm) test
[mg/mL]
ethanol
2g/kg i.p.
8
strains
age
12-16wks
Inbred
Crabbe4
blood ethanol levels following grip strength test at various times after treatment [mg/mL]
ethanol
2g/kg i.p.
time after ethanol:
• 30min
• 60min
• 105min
• 150min
• time comparison
21
strains
age
7-12wks
Inbred
blood — xenobiotics — alcohol concentration
spectrophotometry
Rusyn5
blood alcohol concentration (BAC) [mg/dL]
high-fat diet , ethanol
• high-fat only
• high-fat and ethanol
• comparison
14
strains
age
8-14wks
Inbred
Bennett3
blood ethanol concentration (BEC) [mg/mL]
ethanol
• first loss of balance (ataxia)
• first regain of balance
• second regain of balance
• comparison
72
strains
age
8-14wks
ILSXISS
Bennett3
acute functional tolerance to two-stage injections of EtOH [mg/mL]
ethanol
• as a function of first regain of balance
• as a function of first loss of balance
• comparison
72
strains
age
8-14wks
ILSXISS
blood — xenobiotics — drug and metabolite concentration
flame photometry
Gould1
serum lithium concentration [mmol/L]
lithium
lithium dose [mg/kg]:
• 200
• 300
• 400
• comparison
11
strains
age
7-8wks
Inbred
blood — xenobiotics — drug and metabolite concentration
HPLC
Rusyn2
dichloroacetic acid (serum DCA x 10
-3
) [nmol/mL]
trichloroethylene
treated group:
• 2h
• 8h
• 24h
• time comparison
17
strains
age
7wks
Inbred
Rusyn2
trichloroacetic acid (serum TCA) [nmol/mL]
trichloroethylene
treated group:
• 2h
• 8h
• 24h
• time comparison
17
strains
age
7wks
Inbred
Rusyn2
DCV cysteine (serum DCVC x 10
-3
) [nmol/mL]
trichloroethylene
treated group:
• 2h
• 8h
• 24h
• time comparison
17
strains
age
7wks
Inbred
Rusyn2
DCV glutathione (serum DCVG x 10
-3
) [nmol/mL]
trichloroethylene
treated group:
• 2h
• 8h
• 24h
• time comparison
17
strains
age
7wks
Inbred
Rusyn2
above metabolites compared
trichloroethylene
treated group:
2h
8h
24h
17
strains
age
7wks
Inbred
Threadgill2
serum acetominophen (APAP) [µg/mL] baseline and
acetaminophen
50mg/kg
• baseline
• 0.5h
• 1h
• 2h
• 3h
• 6h
• time comparison
5
strains
age
6-8wks
Inbred
Threadgill2
serum acetaminophen sulfate (APAP-sulfate) [µg/mL] baseline and
acetaminophen
50mg/kg
• baseline
• 0.5h
• 1h
• 2h
• 3h
• 6h
• time comparison
5
strains
age
6-8wks
Inbred
Threadgill2
serum acetaminophen glucuronide (APAP-Glc) [µg/mL] baseline and
acetaminophen
50mg/kg
• baseline
• 0.5h
• 1h
• 2h
• 3h
• 6h
• time comparison
5
strains
age
6-8wks
Inbred
Threadgill2
serum acetominophen (APAP) [µg/mL] baseline and
acetaminophen
300mg/kg
• baseline
• 0.5h
• 1h
• 2h
• 3h
• 6h
• time comparison
5
strains
age
6-8wks
Inbred
Threadgill2
serum acetaminophen sulfate (APAP-sulfate) [µg/mL] baseline and
acetaminophen
300mg/kg
• baseline
• 0.5h
• 1h
• 2h
• 3h
• 6h
• time comparison
5
strains
age
6-8wks
Inbred
Threadgill2
serum acetaminophen glucuronide (APAP-Glc) [µg/mL] baseline and
acetaminophen
300mg/kg
• baseline
• 0.5h
• 1h
• 2h
• 3h
• 6h
• time comparison
5
strains
age
6-8wks
Inbred
Wiltshire2
drug and metabolite concentration [ng/mL]
fluoxetine
• fluoxetine
• norfluoxetine
• comparison
30
strains
age
10-11wks
Inbred
blood — xenobiotics — drug and metabolite concentration
mass spectrometry
Crowley1
plasma haloperidol concentration [nM]
haloperidol
day:
• 30
• 60
• 90
• 120
• time comparison
27
strains
age
9-28wks
Inbred
Gould2
plasma nicotine [ng/mL]
nicotine
• acute 0.09mg dose
• chronic 6.3mg dose
• comparison
8
strains
age
8-12wks
Inbred
Gould2
plasma cotinine [ng/mL]
nicotine
• acute 0.09mg dose
• chronic 6.3mg dose
• comparison
8
strains
age
8-12wks
Inbred
Gould2
compare nicotine vs. cotinine
acute 0.09mg dose
chronic 6.3mg dose
8
strains
age
8-12wks
Inbred
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