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The Mouse Phenome Project was conceptualized at a
Strain Characterization Workshop at The Jackson Laboratory in 1999 where an
international group of physiologists, behaviorists, geneticists, and bioinformaticians
met to discuss the feasibility of a large-scale coordinated community
effort to collect extensive phenotypic data on a standard set of inbred mouse strains.
Workshop participants concluded that:
- Comprehensive phenotypic information on inbred mouse strains is urgently
needed because the laboratory mouse, with its hundreds of inbred, specialized,
and mutant strains, serves as the primary animal model for exploring genetic variation
and human biology.
- Reliable phenotypic data are essential for realizing the full utility of genomic
information that will emerge from sequencing the mouse genome.
- The scope of this large-scale collaborative project requires international cooperation
and both academic and industrial participation.
- Experts in diverse fields of biomedical science should generate this phenotypic data.
- The systematic collection and distribution of strain characteristics data
are critical for advancing biomedical research.
- Selected inbred strains should be methodically tested under standardized
conditions and protocols so that measurements between data sets can be
reliably compared.
- A central, web-accessible database should be developed and housed at The Jackson Laboratory.
and it should enable investigators to identify appropriate strains for:
- physiological testing
- drug discovery
- toxicology studies
- mutagenesis
- disease onset and susceptibility
- new models of human disease
- QTL analyses and identification of new genes
- unraveling the influence of environment on genotype
Sub-committees at the workshop drew up recommendations for
- Standardization and quality controls for testing including:
- inbred strains (priority groups established)
- number of mice
- age
- sex
- environment (temperature, photoperiod)
- housing (bedding, number of animals per cage)
- feed
- health status reports
- Phenotyping assays which would benefit a broad scientific community
Workship participants
Gonzalo Acuna, Hoffman-La Roche, Inc.
Alexander Bachmanov, Monell Chemical Senses Institute
Clint Baldwin, Boston University
Stephen Barthold, University California, Davis
Cory Brayton, Baylor College of Medicine
Robert Cardiff, University California, Davis
Allan Collins, University of Colorado
Allen Cowley Jr., Medical College of Wisconsin
John Crabbe, Oregon Health Sciences University
Muriel Davisson, The Jackson Laboratory
Mariella Debiasi, Baylor College of Medicine
John Forrest, Yale University
Janan Eppig, The Jackson Laboratory
John Hutton, University of Cincinnati
Francois Jenck, Hoffman - La Roche, Inc.
Corrado Jones, Boston University
Monica Justice, Baylor College of Medicine
Steven Kaminsky, Baylor College of Medicine
Barbara Knowles, The Jackson Laboratory
Jeff Lake, The Jackson Laboratory
Trebor Lawton, IDEXX Laboratories, Inc.
John Lorenz, University of Cincinnati
Cheryl Marks, National Cancer Institute
Lloyd Michael, Baylor College of Medicine
David Millhorn, University of Cincinnati
Beverly Paigen, The Jackson Laboratory
Ken Paigen, The Jackson Laboratory
Richard Paylor, Baylor College of Medicine
Lawrence Pinto, Northwestern University
Sohaila Rastan, SmithKline Beecham Pharmaceuticals
Kevin Seburn, The Jackson Laboratory
John Sharp, The Jackson Laboratory
Jan Tornel, AstraZeneca
Doug Wahlsten, University of Alberta
Jeanne Wehner, University of Colorado
David West, Parke-Davis
Richard Woychik, Parke-Davis
Founding Steering Committee
Rudi Balling, GBF-German National Research Centre for Biotechnology
Steve D.M. Brown, Mammalian Genetics Unit, Harwell
Allen Cowley, Jr., Medical College of Wisconsin
Kenneth Fasman, AstraZeneca
Jean-Louis Guenet, Institut Pasteur, France
Steve Kaminsky, Uniformed Services University
Miriam Meisler, University of Michigan Medical School
Kazuo Moriwaki, The Graduate University for Advanced Studies, Japan
Kenneth Paigen, The Jackson Laboratory
Joseph Takahashi, Northwestern University
Richard Woychik, The Jackson Laboratory
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